Cdc37l1 MGI Mouse Gene Detail - MGI:1914322 - cell division cycle 37-like 1

Symbol

Cdc37l1
Name

cell division cycle 37-like 1
Synonyms

2700033A15Rik, Harc, Hsp90-associating relative of Cdc37

Feature Type

protein coding gene
IDs

MGI:1914322
NCBI Gene: 67072
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:28967752-29004081 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 23.61 cM, cytoband C2
Mapping Data

3 experiments

SNPs within 2kb

914 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914322	protein coding gene	Chr19:28959049-29008832 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025015	protein coding gene	Chr19:27420739-27448921 (+)
A/J	MGP_AJ_G0024992	protein coding gene	Chr19:26035682-26063264 (+)
AKR/J	MGP_AKRJ_G0024960	protein coding gene	Chr19:26981847-27010593 (+)
BALB/cJ	MGP_BALBcJ_G0024991	protein coding gene	Chr19:26083391-26110517 (+)
C3H/HeJ	MGP_C3HHeJ_G0024747	protein coding gene	Chr19:26957877-26985712 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025432	protein coding gene	Chr19:28176269-28202910 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022851	protein coding gene	Chr19:26019647-26044464 (+)
CAST/EiJ	MGP_CASTEiJ_G0024217	protein coding gene	Chr19:26782535-26811839 (+)
CBA/J	MGP_CBAJ_G0024725	protein coding gene	Chr19:29512506-29542796 (+)
DBA/2J	MGP_DBA2J_G0024857	protein coding gene	Chr19:25998570-26025448 (+)
FVB/NJ	MGP_FVBNJ_G0024819	protein coding gene	Chr19:25846701-25873650 (+)
LP/J	MGP_LPJ_G0024942	protein coding gene	Chr19:27419771-27448460 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024846	protein coding gene	Chr19:29438372-29470485 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025487	protein coding gene	Chr19:27009006-27037031 (+)
PWK/PhJ	MGP_PWKPhJ_G0023965	protein coding gene	Chr19:25662282-25690526 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023769	protein coding gene	Chr19:26262178-26290558 (+)
WSB/EiJ	MGP_WSBEiJ_G0024284	protein coding gene	Chr19:27040829-27069178 (+)

Human Ortholog

CDC37L1, cell division cycle 37 like 1, HSP90 cochaperone

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDC37L1, cell division cycle 37 like 1, HSP90 cochaperone
Synonyms

CDC37B, HARC
Links

HGNC:17179

NCBI Gene ID: 55664

neXtProt AC: NX_Q7L3B6

UniProt: Q7L3B6
Chr Location

9p24.1; chr9:4679559-4708399 (+) GRCh38

MGI Vertebrate Homology

Cdc37l1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDC37L1
Gene Tree

Cdc37l1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

41
Endonuclease-mediated

1
Gene trapped

39
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

19

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDC37L1

Xenbase cdc37l1

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All Sequences

85
RefSeq

15
UniProt

5
CCDS

CCDS29729.1, CCDS89371.1, CCDS89372.1

Ensembl

ENSMUSG00000024780 (Evidence)
NCBI Gene

67072

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024780	Ensembl Gene Model \| MGI Sequence Detail	36330	C57BL/6J	± kb
transcript	ENSMUST00000050148	Ensembl \| MGI Sequence Detail	5179	Not Applicable
polypeptide	ENSMUSP00000060421	Ensembl \| MGI Sequence Detail	335	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005202 Hsp90 co-chaperone Cdc37-like 1

(term hierarchy)
InterPro Domains

IPR004918 Cdc37

IPR013874 Cdc37, Hsp90 binding

IPR038189 Cdc37, Hsp90-binding domain superfamily
GlyGen

Q9CZP7 1 site, 1 O-linked glycan (1 site)

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All nucleic 25

cDNA 25

Microarray probesets 10

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MGI:2147770

Summaries

All 34

Gene Ontology 4

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdc37l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155754	Chr19:28967747-28967773 (+)	8 bp
Tssr155755	Chr19:28967775-28967792 (+)	32 bp
Tssr155756	Chr19:28967853-28967866 (+)	108 bp
Tssr155757	Chr19:28967876-28967897 (+)	135 bp
Tssr5472	Chr19:28972580-28972595 (+)	4,836 bp
Tssr155758	Chr19:28972603-28972613 (+)	4,856 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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