About   Help   FAQ
Ccdc198 Gene Detail
Summary
  • Symbol
    Ccdc198
  • Name
    coiled-coil domain containing 198
  • Synonyms
    1700011H14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914332
    NCBI Gene: 67082
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:49463815-49482902 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 25.46 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    613 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914332
 protein coding gene Chr14:49457045-49482931 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021231
 protein coding gene Chr14:43126101-43150316 (-)
A/J MGP_AJ_G0021180
 protein coding gene Chr14:41760376-41783341 (-)
AKR/J MGP_AKRJ_G0021158
 protein coding gene Chr14:43391626-43417537 (-)
BALB/cJ MGP_BALBcJ_G0021183
 protein coding gene Chr14:41819882-41844915 (-)
C3H/HeJ MGP_C3HHeJ_G0020966
 protein coding gene Chr14:43175786-43198858 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021618
 protein coding gene Chr14:44894693-44913767 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019177
 protein coding gene Chr14:41059334-41082640 (-)
CAST/EiJ MGP_CASTEiJ_G0020492
 protein coding gene Chr14:40303059-40329972 (-)
CBA/J MGP_CBAJ_G0020933
 protein coding gene Chr14:46321166-46346069 (-)
DBA/2J MGP_DBA2J_G0021056
 protein coding gene Chr14:41635383-41658283 (-)
FVB/NJ MGP_FVBNJ_G0021041
 protein coding gene Chr14:41378987-41401810 (-)
LP/J MGP_LPJ_G0021125
 protein coding gene Chr14:43382282-43405195 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021066
 protein coding gene Chr14:45647233-45670276 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021651
 protein coding gene Chr14:42921066-42944045 (-)
PWK/PhJ MGP_PWKPhJ_G0020240
 protein coding gene Chr14:38546280-38569605 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020065
 protein coding gene Chr14:39038124-39058131 (-)
WSB/EiJ MGP_WSBEiJ_G0020548
 protein coding gene Chr14:43021142-43052959 (-)



Homology
more
  • Human Ortholog
    CCDC198, coiled-coil domain containing 198
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC198, coiled-coil domain containing 198
  • Synonyms
    C14orf105, FAME
  • Links
    NCBI Gene ID: 55195
    neXtProt AC: NX_Q9NVL8
    UniProt: Q9NVL8

  • Chr Location
    14q22.3; chr14:57469300-57493867 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
On the FVB/Ant background knockout mice show increased body weight, decreased locomotor activity, reduced serum ferritin levels, albuminuria, thrombocytopenia (females only), and a reduced size of kidneys, adrenal glands, interscapular brown adipose tissue and liver, which is analogous to control mice on a low iron diet. Analysis of a second knockout model on the C57BL/6NCrl background reveals significant effects in metabolic cage experiments, including differences in body weight and lean body mass, day/night activity, food intake, and energy expenditure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    39
  • cDNA Data
    28
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67082 NCBI Gene Model | MGI Sequence Detail 19088 C57BL/6J ±  kb
    transcript NM_025956 RefSeq | MGI Sequence Detail 1167 C57BL/6  
    polypeptide Q9CPZ1 UniProt | EBI | MGI Sequence Detail 294 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:6156351
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 5
      Gene Ontology 1
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory