Psmc6 MGI Mouse Gene Detail - MGI:1914339 - proteasome (prosome, macropain) 26S subunit, ATPase, 6

Symbol

Psmc6
Name

proteasome (prosome, macropain) 26S subunit, ATPase, 6
Synonyms

2300001E01Rik

Feature Type

protein coding gene
IDs

MGI:1914339
NCBI Gene: 67089
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:45567285-45587150 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 22.89 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

539 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914339	protein coding gene	Chr14:45567245-45587162 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021207	protein coding gene	Chr14:38951119-38970853 (+)
A/J	MGP_AJ_G0021153	protein coding gene	Chr14:37794637-37814520 (+)
AKR/J	MGP_AKRJ_G0021131	protein coding gene	Chr14:39278184-39297916 (+)
BALB/cJ	MGP_BALBcJ_G0021157	protein coding gene	Chr14:37844986-37864869 (+)
C3H/HeJ	MGP_C3HHeJ_G0020940	protein coding gene	Chr14:39085714-39106272 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021591	protein coding gene	Chr14:40645381-40665115 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019150	protein coding gene	Chr14:37223472-37244321 (+)
CAST/EiJ	MGP_CASTEiJ_G0020465	protein coding gene	Chr14:36205030-36224712 (+)
CBA/J	MGP_CBAJ_G0020906	protein coding gene	Chr14:41939624-41960009 (+)
DBA/2J	MGP_DBA2J_G0021029	protein coding gene	Chr14:37717158-37736913 (+)
FVB/NJ	MGP_FVBNJ_G0021013	protein coding gene	Chr14:37474547-37494281 (+)
LP/J	MGP_LPJ_G0021099	protein coding gene	Chr14:39238600-39258337 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021039	protein coding gene	Chr14:41340657-41362547 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021624	protein coding gene	Chr14:38815486-38835220 (+)
PWK/PhJ	MGP_PWKPhJ_G0020214	protein coding gene	Chr14:34578313-34598572 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020036	protein coding gene	Chr14:34975390-34995600 (+)
WSB/EiJ	MGP_WSBEiJ_G0020521	protein coding gene	Chr14:38926658-38946400 (+)

Human Ortholog

PSMC6, proteasome 26S subunit, ATPase 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PSMC6, proteasome 26S subunit, ATPase 6
Synonyms

p42, RPT5, SUG2
Links

HGNC:9553

NCBI Gene ID: 5706

neXtProt AC: NX_P62333

UniProt: P62333
Chr Location

14q22.1; chr14:52707178-52728590 (+) GRCh38

MGI Vertebrate Homology

Psmc6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PSMC6
Gene Tree

Psmc6

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

16
Targeted

3
Genomic Mutations

1 involving Psmc6
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

20
cDNA Data

177
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase psmc6

ZFIN psmc6

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All Sequences

57
RefSeq

4
UniProt

5
CCDS

CCDS26974.1

Ensembl

ENSMUSG00000021832 (Evidence)
NCBI Gene

67089

			Length	Strain/Species	Flank
genomic	67089	NCBI Gene Model \| MGI Sequence Detail	19866	C57BL/6J	± kb
transcript	NM_001416015	RefSeq \| MGI Sequence Detail	2353	C57BL/6
polypeptide	P62334	UniProt \| EBI \| MGI Sequence Detail	389	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013384 26S proteasome regulatory subunit 10B

(term hierarchy)
InterPro Domains

IPR050221 26S Proteasome Regulatory ATPase

IPR041569 AAA ATPase, AAA+ lid domain

IPR003593 AAA+ ATPase domain

IPR003960 ATPase, AAA-type, conserved site

IPR003959 ATPase, AAA-type, core

IPR012340 Nucleic acid-binding, OB-fold

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR032501 Proteasomal ATPase, second OB domain

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All nucleic 178

cDNA 177

Primer pair 1

Microarray probesets 6

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MGI:2145653

Summaries

All 45

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Psmc6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125213	Chr14:45567257-45567268 (+)	-22 bp
Tssr125214	Chr14:45567272-45567306 (+)	4 bp
Tssr125215	Chr14:45574970-45574988 (+)	7,694 bp
Tssr125216	Chr14:45578732-45578767 (+)	11,465 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24