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Trappc6a Gene Detail
Summary
  • Symbol
    Trappc6a
  • Name
    trafficking protein particle complex 6A
  • Synonyms
    1810073E21Rik, 4930519D19Rik, TRS33
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914341
    NCBI Gene: 67091
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19242595-19250070 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.92 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    301 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914341
 protein coding gene Chr7:19242320-19250070 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031781
 protein coding gene Chr7:17524462-17537039 (+)
A/J MGP_AJ_G0031757
 protein coding gene Chr7:17154473-17163157 (+)
AKR/J MGP_AKRJ_G0031683
 protein coding gene Chr7:17630180-17640144 (+)
BALB/cJ MGP_BALBcJ_G0031762
 protein coding gene Chr7:17361008-17368938 (+)
C3H/HeJ MGP_C3HHeJ_G0031484
 protein coding gene Chr7:17892864-17901222 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032228
 protein coding gene Chr7:18396443-18404352 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029294
 protein coding gene Chr7:18805828-18812080 (+)
CAST/EiJ MGP_CASTEiJ_G0030828
 protein coding gene Chr7:14329144-14337594 (+)
CBA/J MGP_CBAJ_G0031446
 protein coding gene Chr7:19054526-19069193 (+)
DBA/2J MGP_DBA2J_G0031601
 protein coding gene Chr7:17103165-17110837 (+)
FVB/NJ MGP_FVBNJ_G0031553
 protein coding gene Chr7:16962024-16970561 (+)
LP/J MGP_LPJ_G0031684
 protein coding gene Chr7:17844776-17855530 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031589
 protein coding gene Chr7:18904260-18914434 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032256
 protein coding gene Chr7:17233196-17242581 (+)
PWK/PhJ MGP_PWKPhJ_G0030551
 protein coding gene Chr7:14202435-14211253 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030378
 protein coding gene Chr7:11943373-11949872 (+)
WSB/EiJ MGP_WSBEiJ_G0030927
 protein coding gene Chr7:17456909-17465770 (+)



Homology
more
  • Human Ortholog
    TRAPPC6A, trafficking protein particle complex subunit 6A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAPPC6A, trafficking protein particle complex subunit 6A
  • Synonyms
    TRS33
  • Links
    NCBI Gene ID: 79090
    neXtProt AC: NX_O75865
    UniProt: O75865

  • Chr Location
    19q13.32; chr19:45162928-45178237 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice exhibit pigmentation abnormalities including mosaic loss of coat pigment, patchy loss of pigmentation in the retinal pigmented epithelial layer, and abnormal melanosomes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67091 NCBI Gene Model | MGI Sequence Detail 7476 C57BL/6J ±  kb
    transcript NM_025960 RefSeq | MGI Sequence Detail 827 C57BL/6  
    polypeptide Q78XR0 UniProt | EBI | MGI Sequence Detail 159 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000016617 trafficking protein particle complex subunit 6A
      (term hierarchy)
    • InterPro Domains
      IPR024096 NO signalling/Golgi transport ligand-binding domain superfamily
      IPR007194 Transport protein particle (TRAPP) component
      IPR037992 TRAPP complex, Trs33 subunit
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922355, MGI:2141982, MGI:3577867
    References
    more
    • Summaries
      All 29
      Gene Ontology 3
      Phenotypes 5
    • Earliest
      J:14372 Matthews RJ, et al., Identification of an additional member of the protein-tyrosine-phosphatase family: evidence for alternative splicing in the tyrosine phosphatase domain. Proc Natl Acad Sci U S A. 1990 Jun;87(12):4444-8
    • Latest
      J:320033 Kim JJ, et al., TRAPP Complexes in Secretion and Autophagy. Front Cell Dev Biol. 2016;4:20
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory