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Nrarp Gene Detail
Summary
  • Symbol
    Nrarp
  • Name
    Notch-regulated ankyrin repeat protein
  • Synonyms
    2700054M22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914372
    NCBI Gene: 67122
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25070770-25073351 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914372
 protein coding gene Chr2:25070770-25073351 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025421
 protein coding gene Chr2:23039771-23042352 (+)
A/J MGP_AJ_G0025398
 protein coding gene Chr2:22145633-22148214 (+)
AKR/J MGP_AKRJ_G0025368
 protein coding gene Chr2:22899640-22902221 (+)
BALB/cJ MGP_BALBcJ_G0025394
 protein coding gene Chr2:22267949-22270530 (+)
C3H/HeJ MGP_C3HHeJ_G0025155
 protein coding gene Chr2:22829313-22831894 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025838
 protein coding gene Chr2:23776322-23778903 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023249
 protein coding gene Chr2:21076801-21079380 (+)
CAST/EiJ MGP_CASTEiJ_G0024618
 protein coding gene Chr2:22713125-22715706 (+)
CBA/J MGP_CBAJ_G0025133
 protein coding gene Chr2:24613863-24616444 (+)
DBA/2J MGP_DBA2J_G0025266
 protein coding gene Chr2:22001912-22004493 (+)
FVB/NJ MGP_FVBNJ_G0025228
 protein coding gene Chr2:21740690-21743271 (+)
LP/J MGP_LPJ_G0025352
 protein coding gene Chr2:22991033-22993614 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025259
 protein coding gene Chr2:24818411-24820992 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025897
 protein coding gene Chr2:22846379-22848960 (+)
PWK/PhJ MGP_PWKPhJ_G0024366
 protein coding gene Chr2:21812881-21815461 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024166
 protein coding gene Chr2:22994577-22997156 (+)
WSB/EiJ MGP_WSBEiJ_G0024687
 protein coding gene Chr2:22916650-22919231 (+)



Homology
more
  • Human Ortholog
    NRARP, NOTCH regulated ankyrin repeat protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRARP, NOTCH regulated ankyrin repeat protein
  • Links
    NCBI Gene ID: 441478
    neXtProt AC: NX_Q7Z6K4
    UniProt: Q7Z6K4

  • Chr Location
    9q34.3; chr9:137299631-137302271 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 6 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit delayed retinal vascularization due to increased vascular regression. Mice homozygous for a different knock-out allele exhibit vertebral and rib fusions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1026
  • Tissues
    94
  • cDNA Data
    50
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67122 NCBI Gene Model | MGI Sequence Detail 2582 C57BL/6J ±  kb
    transcript NM_025980 RefSeq | MGI Sequence Detail 2590 AKR/J  
    polypeptide Q91ZA8 UniProt | EBI | MGI Sequence Detail 114 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 51
      Primer pair 2
      Other 5

      Microarray probesets 5
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 32
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:348800 Clark JF, et al., Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development. Genes Dev. 2024 Jun 4;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory