Lce1a1 Gene Detail

Summary

• Symbol
  Lce1a1
• Name
  late cornified envelope 1A1
• Synonyms
  2200008B06Rik, Sprrl3

• Feature Type
  protein coding gene
• IDs
  MGI:1914377
  NCBI Gene: 67127
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr3:92553842-92555614 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 40.14 cM, cytoband F2
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  194 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914377	protein coding gene	Chr3:92553839-92555614 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027506	protein coding gene	Chr3:93101759-93104255 (-)
A/J	MGP_AJ_G0027473	protein coding gene	Chr3:90172614-90174231 (-)
AKR/J	MGP_AKRJ_G0027438	protein coding gene	Chr3:92289130-92290862 (-)
BALB/cJ	MGP_BALBcJ_G0027481	protein coding gene	Chr3:89982741-89984470 (-)
C3H/HeJ	MGP_C3HHeJ_G0027221	protein coding gene	Chr3:92510857-92512597 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027925	protein coding gene	Chr3:96648028-96650049 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025275	protein coding gene	Chr3:86802099-86803912 (-)
CAST/EiJ	MGP_CASTEiJ_G0026669	protein coding gene	Chr3:91922982-91926159 (-)
CBA/J	MGP_CBAJ_G0027195	protein coding gene	Chr3:99966479-99968220 (-)
DBA/2J	MGP_DBA2J_G0027333	protein coding gene	Chr3:89494693-89496719 (-)
FVB/NJ	MGP_FVBNJ_G0027301	protein coding gene	Chr3:87662867-87664639 (-)
LP/J	MGP_LPJ_G0027441	protein coding gene	Chr3:94321423-94324247 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027326	protein coding gene	Chr3:106245973-106247740 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027984	protein coding gene	Chr3:92017930-92019671 (-)
PWK/PhJ	MGP_PWKPhJ_G0026402	protein coding gene	Chr3:89374951-89376772 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026220	protein coding gene	Chr3:90347551-90349675 (-)
WSB/EiJ	MGP_WSBEiJ_G0026751	protein coding gene	Chr3:92398103-92403794 (-)

Homology

• MGI Vertebrate Homology
  Lce1a1 stringent orthology
  1 mouse;1 rat
  
• Gene Tree
  Lce1a1
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Endonuclease-mediated
  2
• Radiation induced
  1
• Targeted
  1
• Genomic Mutations
  2 involving Lce1a1
• Incidental Mutations
  APF
• Find Mice (IMSR)
  7 strains or lines available

Expression

• Assay Results
  706
• cDNA Data
  16
• Literature Summary
  2

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  31
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS17562.1

• Ensembl
  ENSMUSG00000057609 (Evidence)
• NCBI Gene
  67127

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000057609	Ensembl Gene Model | MGI Sequence Detail	1773	C57BL/6J
transcript	ENSMUST00000074142	Ensembl | MGI Sequence Detail	705	Not Applicable
polypeptide	ENSMUSP00000073776	Ensembl | MGI Sequence Detail	143	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR028205 Late cornified envelope protein

Molecular
Reagents

• All nucleic 16

  cDNA 16

  
  

  Microarray probesets 5

References

• Summaries
  All 25

  Developmental Gene Expression 2

  Diseases 1

  Phenotypes 6
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Lce1a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34324	Chr3:92555610-92555615 (-)	1 bp
Tssr34323	Chr3:92554687-92554692 (-)	924 bp