Ndufa6 MGI Mouse Gene Detail - MGI:1914380 - NADH:ubiquinone oxidoreductase subunit A6

Symbol

Ndufa6
Name

NADH:ubiquinone oxidoreductase subunit A6
Synonyms

14kDa, B230217P19Rik

Feature Type

protein coding gene
IDs

MGI:1914380
NCBI Gene: 67130
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:82234342-82238438 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.56 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

262 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914380	protein coding gene	Chr15:82234341-82238523 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022145	protein coding gene	Chr15:82864782-82868912 (-)
A/J	MGP_AJ_G0022105	protein coding gene	Chr15:79925380-79929508 (-)
AKR/J	MGP_AKRJ_G0022081	protein coding gene	Chr15:82146092-82150234 (-)
BALB/cJ	MGP_BALBcJ_G0022111	protein coding gene	Chr15:79975293-79980596 (-)
C3H/HeJ	MGP_C3HHeJ_G0021882	protein coding gene	Chr15:82168449-82173949 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022554	protein coding gene	Chr15:86106304-86110637 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020083	protein coding gene	Chr15:76357511-76361515 (-)
CAST/EiJ	MGP_CASTEiJ_G0021402	protein coding gene	Chr15:82954751-82960108 (-)
CBA/J	MGP_CBAJ_G0021847	protein coding gene	Chr15:88813923-88818069 (-)
DBA/2J	MGP_DBA2J_G0021975	protein coding gene	Chr15:79392996-79397134 (-)
FVB/NJ	MGP_FVBNJ_G0021952	protein coding gene	Chr15:78463542-78467647 (-)
LP/J	MGP_LPJ_G0022044	protein coding gene	Chr15:83013741-83018213 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021973	protein coding gene	Chr15:93696718-93701669 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022568	protein coding gene	Chr15:82257802-82261946 (-)
PWK/PhJ	MGP_PWKPhJ_G0021144	protein coding gene	Chr15:79453393-79457498 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020983	protein coding gene	Chr15:82032726-82036794 (-)
WSB/EiJ	MGP_WSBEiJ_G0021453	protein coding gene	Chr15:82682577-82686709 (-)

Human Ortholog

NDUFA6, NADH:ubiquinone oxidoreductase subunit A6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NDUFA6, NADH:ubiquinone oxidoreductase subunit A6
Synonyms

B14, CI-B14, LYRM6, MC1DN33, NADHB14
Links

HGNC:7690

NCBI Gene ID: 4700

neXtProt AC: NX_P56556

UniProt: P56556
Chr Location

22q13.2; chr22:42085526-42090884 (-) GRCh38

MGI Vertebrate Homology

Ndufa6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NDUFA6
Protein SuperFamily

NDUA6
Gene Tree

Ndufa6

Diseases

1 with human NDUFA6 associations

				Human Disease	Mouse Models
				nuclear type mitochondrial complex I deficiency 33 IDs nuclear type mitochondrial complex I deficiency 33 DOID:0112097 OMIM:618253

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

less

Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

15
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Ndufa6
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

14
GO References

8

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

96
cDNA Data

104
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ndufa6

ZFIN ndufa6

less

All Sequences

44
RefSeq

2
UniProt

4
CCDS

CCDS27689.1

Ensembl

ENSMUSG00000022450 (Evidence)
NCBI Gene

67130

			Length	Strain/Species	Flank
genomic	67130	NCBI Gene Model \| MGI Sequence Detail	4097	C57BL/6J	± kb
transcript	NM_025987	RefSeq \| MGI Sequence Detail	504	C57BL/6
polypeptide	Q9CQZ5	UniProt \| EBI \| MGI Sequence Detail	131	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000011077 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

(term hierarchy)
PDB

6G2J, 6G72, 6ZR2, 6ZTQ, 7AK5, 7AK6, 7B93, 7PSA, 8C2S, 8CA3, 8CA5, 8OLT, 8OM1, 8PW5, 8PW6, 8PW7, 8RGP, 8RGQ, 8RGR, 8RGT
InterPro Domains

IPR016488 NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 6

IPR045299 NDUFA6, LYR domain
GlyGen

Q9CQZ5 1 site, 1 O-linked glycan (1 site)

less

All nucleic 106

cDNA 105

Primer pair 1

Microarray probesets 4

less

MGI:1926087

Summaries

All 58

Developmental Gene Expression 3

Diseases 1

Gene Ontology 8

Phenotypes 27
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071

TSS for Ndufa6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135549	Chr15:82238513-82238524 (-)	-81 bp
Tssr135548	Chr15:82238481-82238492 (-)	-49 bp
Tssr135547	Chr15:82238426-82238462 (-)	-6 bp
Tssr135546	Chr15:82238395-82238409 (-)	36 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24