Rnaseh2b MGI Mouse Gene Detail - MGI:1914403

Symbol

Rnaseh2b
Name

ribonuclease H2, subunit B
Synonyms

1110019N06Rik, 2610207P08Rik, Dleu8

Feature Type

protein coding gene
IDs

MGI:1914403
NCBI Gene: 67153
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr14:62569517-62610445 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 33.19 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

1429 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914403	protein coding gene	Chr14:62530038-62610445 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021445	protein coding gene	Chr14:56724384-56809108 (+)
A/J	MGP_AJ_G0021404	protein coding gene	Chr14:55463926-55544979 (+)
AKR/J	MGP_AKRJ_G0021380	protein coding gene	Chr14:57446739-57530383 (+)
BALB/cJ	MGP_BALBcJ_G0021410	protein coding gene	Chr14:55416125-55502337 (+)
C3H/HeJ	MGP_C3HHeJ_G0021187	protein coding gene	Chr14:57068182-57152767 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021849	protein coding gene	Chr14:59451955-59534352 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019389	protein coding gene	Chr14:53474000-53514465 (+)
CAST/EiJ	MGP_CASTEiJ_G0020704	protein coding gene	Chr14:53488198-53580216 (+)
CBA/J	MGP_CBAJ_G0021154	protein coding gene	Chr14:61187821-61279032 (+)
DBA/2J	MGP_DBA2J_G0021277	protein coding gene	Chr14:55135967-55216254 (+)
FVB/NJ	MGP_FVBNJ_G0021256	protein coding gene	Chr14:54544202-54631288 (+)
LP/J	MGP_LPJ_G0021352	protein coding gene	Chr14:57768313-57850551 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021285	protein coding gene	Chr14:60502436-60585149 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021872	protein coding gene	Chr14:56589630-56673024 (+)
PWK/PhJ	MGP_PWKPhJ_G0020448	protein coding gene	Chr14:51805647-51888389 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020281	protein coding gene	Chr14:52560132-52656461 (+)
WSB/EiJ	MGP_WSBEiJ_G0020757	protein coding gene	Chr14:56906286-56989282 (+)

Human Ortholog

RNASEH2B, ribonuclease H2 subunit B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNASEH2B, ribonuclease H2 subunit B
Synonyms

AGS2, DLEU8
Links

HGNC:25671

NCBI Gene ID: 79621

neXtProt AC: NX_Q5TBB1

UniProt: Q5TBB1
Chr Location

13q14.3; chr13:50909678-51024120 (+) GRCh38

MGI Vertebrate Homology

Rnaseh2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNASEH2B
Gene Tree

Rnaseh2b

Diseases

1 with human RNASEH2B associations

				Human Disease	Mouse Models
				Aicardi-Goutieres syndrome IDs Aicardi-Goutieres syndrome DOID:0050629 ICD10CM:G31.8 OMIM:225750 OMIM:610181 OMIM:610329 OMIM:610333 OMIM:612952 OMIM:615010 OMIM:615846 OMIM:PS225750 ORDO:51

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

20 phenotypes from 4 alleles in 5 genetic backgrounds
17 phenotypes from multigenic genotypes
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

52
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

41
Targeted

8
Genomic Mutations

2 involving Rnaseh2b
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit preweaning lethality associated with reduced cell proliferation and embryonic growth retardation.

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All GO Annotations

20
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

29
cDNA Data

41
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnaseh2b

ZFIN rnaseh2b

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All Sequences

41
RefSeq

2
UniProt

3
CCDS

CCDS27189.1

Ensembl

ENSMUSG00000021932 (Evidence)
NCBI Gene

67153

			Length	Strain/Species	Flank
genomic	67153	NCBI Gene Model \| MGI Sequence Detail	40929	C57BL/6J	± kb
transcript	NM_026001	RefSeq \| MGI Sequence Detail	1498	C57BL/6
polypeptide	Q80ZV0	UniProt \| EBI \| MGI Sequence Detail	308	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014055 ribonuclease H2 subunit B

(term hierarchy)
PDB

3KIO, 3P5J
InterPro Domains

IPR040456 Ribonuclease H2 subunit B

IPR019024 Ribonuclease H2 subunit B, wHTH domain

IPR041195 Rnh202, triple barrel domain

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All nucleic 43

cDNA 42

Primer pair 1

Microarray probesets 4

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MGI:1915767

Summaries

All 56

Developmental Gene Expression 5

Diseases 1

Gene Ontology 6

Phenotypes 27
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rnaseh2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126003	Chr14:62569534-62569559 (+)	30 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24