Ctdnep1 MGI Mouse Gene Detail - MGI:1914431 - CTD nuclear envelope phosphatase 1

Symbol

Ctdnep1
Name

CTD nuclear envelope phosphatase 1
Synonyms

2610507E10Rik, Dullard

Feature Type

protein coding gene
IDs

MGI:1914431
NCBI Gene: 67181
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:69871994-69881427 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.95 cM, cytoband B4
Mapping Data

2 experiments

SNPs within 2kb

70 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914431	protein coding gene	Chr11:69871982-69881427 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018574	protein coding gene	Chr11:70474385-70484982 (+)
A/J	MGP_AJ_G0018542	protein coding gene	Chr11:67806537-67815407 (+)
AKR/J	MGP_AKRJ_G0018511	protein coding gene	Chr11:69827866-69836761 (+)
BALB/cJ	MGP_BALBcJ_G0018514	protein coding gene	Chr11:68135063-68143950 (+)
C3H/HeJ	MGP_C3HHeJ_G0018327	protein coding gene	Chr11:69865891-69874820 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018965	protein coding gene	Chr11:72597815-72607242 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016610	protein coding gene	Chr11:64730338-64739945 (+)
CAST/EiJ	MGP_CASTEiJ_G0017882	protein coding gene	Chr11:70109734-70119560 (+)
CBA/J	MGP_CBAJ_G0018299	protein coding gene	Chr11:75854377-75866605 (+)
DBA/2J	MGP_DBA2J_G0018409	protein coding gene	Chr11:67391194-67399897 (+)
FVB/NJ	MGP_FVBNJ_G0018399	protein coding gene	Chr11:67038667-67047363 (+)
LP/J	MGP_LPJ_G0018479	protein coding gene	Chr11:71056538-71066109 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018422	protein coding gene	Chr11:76444786-76454786 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019007	protein coding gene	Chr11:70100686-70109594 (+)
PWK/PhJ	MGP_PWKPhJ_G0017656	protein coding gene	Chr11:68042514-68051332 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017446	protein coding gene	Chr11:69918616-69927272 (+)
WSB/EiJ	MGP_WSBEiJ_G0017936	protein coding gene	Chr11:69765026-69773722 (+)

Human Ortholog

CTDNEP1, CTD nuclear envelope phosphatase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTDNEP1, CTD nuclear envelope phosphatase 1
Synonyms

DULLARD, HSA011916, NET56
Links

HGNC:19085

NCBI Gene ID: 23399

neXtProt AC: NX_O95476

UniProt: O95476
Chr Location

17p13.1; chr17:7243591-7252491 (-) GRCh38

MGI Vertebrate Homology

Ctdnep1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CTDNEP1
Gene Tree

Ctdnep1

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Phenotype Summary

20 phenotypes from 3 alleles in 4 genetic backgrounds
3 phenotypes from multigenic genotypes
3 images
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Gene trapped

5
Targeted

7
Genomic Mutations

2 involving Ctdnep1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality, abnormal extraembryonic tissue development, poorly developed head fold and trunk and severely reduced primordial germ cell numbers due to a failure to transit to mesoderm.

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All GO Annotations

42
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

7
cDNA Data

107
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctdnep1

ZFIN ctdnep1a, ctdnep1b

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS24927.1

Ensembl

ENSMUSG00000018559 (Evidence)
NCBI Gene

67181

			Length	Strain/Species	Flank
genomic	67181	NCBI Gene Model \| MGI Sequence Detail	9434	C57BL/6J	± kb
transcript	NM_026017	RefSeq \| MGI Sequence Detail	1615	C57BL/6
polypeptide	Q3TP92	UniProt \| EBI \| MGI Sequence Detail	244	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006726 serine/threonine-protein phosphatase dullard

(term hierarchy)
EC

3.1.3.16
InterPro Domains

IPR011948 Dullard phosphatase domain, eukaryotic

IPR004274 FCP1 homology domain

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR050365 Mitochondrial import inner membrane translocase subunit TIM50

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All nucleic 107

cDNA 107

Microarray probesets 3

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 20
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:333381 Luo Z, et al., Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability. Nat Commun. 2023 Feb 10;14(1):762

TSS for Ctdnep1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102590	Chr11:69871656-69871667 (+)	-332 bp
Tssr102591	Chr11:69871865-69871912 (+)	-105 bp
Tssr102592	Chr11:69871953-69872040 (+)	3 bp
Tssr102593	Chr11:69872081-69872086 (+)	90 bp
Tssr102594	Chr11:69872158-69872195 (+)	183 bp
Tssr102595	Chr11:69872207-69872216 (+)	218 bp
Tssr102596	Chr11:69872286-69872297 (+)	298 bp
Tssr102597	Chr11:69872301-69872306 (+)	310 bp
Tssr102598	Chr11:69872317-69872328 (+)	329 bp
Tssr102599	Chr11:69872348-69872359 (+)	360 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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