Srfbp1 MGI Mouse Gene Detail - MGI:1914472 - serum response factor binding protein 1

Symbol

Srfbp1
Name

serum response factor binding protein 1
Synonyms

2810036K01Rik

Feature Type

protein coding gene
IDs

MGI:1914472
NCBI Gene: 67222
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr18:52598765-52625003 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 28.21 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

1148 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914472	protein coding gene	Chr18:52598703-52625005 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024427	protein coding gene	Chr18:51584717-51611765 (+)
A/J	MGP_AJ_G0024393	protein coding gene	Chr18:49593026-49623187 (+)
AKR/J	MGP_AKRJ_G0024363	protein coding gene	Chr18:50984243-51013269 (+)
BALB/cJ	MGP_BALBcJ_G0024393	protein coding gene	Chr18:49765170-49790911 (+)
C3H/HeJ	MGP_C3HHeJ_G0024160	protein coding gene	Chr18:51119271-51144464 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024839	protein coding gene	Chr18:53313921-53340133 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022271	protein coding gene	Chr18:49400901-49426417 (+)
CAST/EiJ	MGP_CASTEiJ_G0023634	protein coding gene	Chr18:51074055-51101471 (+)
CBA/J	MGP_CBAJ_G0024130	protein coding gene	Chr18:54872605-54915158 (+)
DBA/2J	MGP_DBA2J_G0024260	protein coding gene	Chr18:49303724-49328934 (+)
FVB/NJ	MGP_FVBNJ_G0024227	protein coding gene	Chr18:48738437-48763902 (+)
LP/J	MGP_LPJ_G0024345	protein coding gene	Chr18:51612242-51639798 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024257	protein coding gene	Chr18:56653306-56680670 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024886	protein coding gene	Chr18:50989433-51022732 (+)
PWK/PhJ	MGP_PWKPhJ_G0023378	protein coding gene	Chr18:49328362-49353352 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023184	protein coding gene	Chr18:51174021-51203585 (+)
WSB/EiJ	MGP_WSBEiJ_G0023697	protein coding gene	Chr18:50901017-50932571 (+)

Human Ortholog

SRFBP1, serum response factor binding protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRFBP1, serum response factor binding protein 1
Synonyms

BUD22, P49, p49/STRAP, Rlb1, STRAP
Links

HGNC:26333

NCBI Gene ID: 153443

neXtProt AC: NX_Q8NEF9

UniProt: Q8NEF9
Chr Location

5q23.1; chr5:121961975-122078935 (+) GRCh38

MGI Vertebrate Homology

Srfbp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SRFBP1
Gene Tree

Srfbp1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
1 images
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

2
Gene trapped

10
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Srfbp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available

Mice homozygous for a knock-out allele show embryonic growth retardation and complete embryonic lethality before implantation. In vitro, embryos fail to hatch from the zona pellucida and die after 3 days in culture.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

754
Tissues

11
cDNA Data

44
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srfbp1

ZFIN srfbp1

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All Sequences

43
RefSeq

3
UniProt

2
CCDS

CCDS37819.1

Ensembl

ENSMUSG00000024528 (Evidence)
NCBI Gene

67222

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024528	Ensembl Gene Model \| MGI Sequence Detail	26239	C57BL/6J	± kb
transcript	ENSMUST00000025406	Ensembl \| MGI Sequence Detail	2656	Not Applicable
polypeptide	ENSMUSP00000025406	Ensembl \| MGI Sequence Detail	441	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015614 serum response factor-binding protein 1

(term hierarchy)
InterPro Domains

IPR015158 Bud22 domain

IPR037393 Bud22/Serum response factor-binding protein 1

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All nucleic 46

cDNA 44

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:327181 Lewis MA, et al., Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme. BMC Biol. 2022 Mar 17;20(1):67

TSS for Srfbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151044	Chr18:52598748-52598782 (+)	0 bp
Tssr151045	Chr18:52619223-52619239 (+)	20,466 bp
Tssr151046	Chr18:52621445-52621453 (+)	22,684 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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