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Prpf18 Gene Detail
Summary
  • Symbol
    Prpf18
  • Name
    pre-mRNA processing factor 18
  • Synonyms
    2810441A10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914479
    NCBI Gene: 67229
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:4626869-4656924 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 2.79 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    888 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914479
 protein coding gene Chr2:4626869-4656946 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025314
 protein coding gene Chr2:1673998-1705787 (-)
A/J MGP_AJ_G0025291
 protein coding gene Chr2:1598502-1630172 (-)
AKR/J MGP_AKRJ_G0025259
 protein coding gene Chr2:1630313-1660088 (-)
BALB/cJ MGP_BALBcJ_G0025287
 protein coding gene Chr2:1571093-1601234 (-)
C3H/HeJ MGP_C3HHeJ_G0025047
 protein coding gene Chr2:1619403-1651442 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025729
 protein coding gene Chr2:1687846-1720543 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023143
 protein coding gene Chr2:1455820-1487901 (-)
CAST/EiJ MGP_CASTEiJ_G0024510
 protein coding gene Chr2:1620518-1653910 (-)
CBA/J MGP_CBAJ_G0025026
 protein coding gene Chr2:1764598-1796888 (-)
DBA/2J MGP_DBA2J_G0025158
 protein coding gene Chr2:1569091-1599187 (-)
FVB/NJ MGP_FVBNJ_G0025120
 protein coding gene Chr2:1560690-1590582 (-)
LP/J MGP_LPJ_G0025244
 protein coding gene Chr2:1653580-1689954 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025152
 protein coding gene Chr2:1677927-1711116 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025787
 protein coding gene Chr2:1628106-1661195 (-)
PWK/PhJ MGP_PWKPhJ_G0024260
 protein coding gene Chr2:1539701-1571233 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024061
 protein coding gene Chr2:1640722-1669636 (-)
WSB/EiJ MGP_WSBEiJ_G0024580
 protein coding gene Chr2:1639960-1676452 (-)



Homology
more
  • Human Ortholog
    PRPF18, pre-mRNA processing factor 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRPF18, pre-mRNA processing factor 18
  • Synonyms
    hPrp18, PRP18
  • Links
    NCBI Gene ID: 8559
    neXtProt AC: NX_Q99633
    UniProt: Q99633

  • Chr Location
    10p13; chr10:13586939-13668445 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    919
  • Tissues
    80
  • cDNA Data
    85
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039449 Ensembl Gene Model | MGI Sequence Detail 30056 C57BL/6J ±  kb
transcript ENSMUST00000152362 Ensembl | MGI Sequence Detail 1579 Not Applicable  
polypeptide ENSMUSP00000116495 Ensembl | MGI Sequence Detail 342 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 87
    cDNA 85
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory