Cul4a MGI Mouse Gene Detail - MGI:1914487

Symbol

Cul4a
Name

cullin 4A
Synonyms

2810470J21Rik

Feature Type

protein coding gene
IDs

MGI:1914487
NCBI Gene: 99375
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr8:13155623-13197940 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 5.73 cM
Mapping Data

2 experiments

SNPs within 2kb

1104 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914487	protein coding gene	Chr8:13155621-13197940 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033372	protein coding gene	Chr8:10421766-10464907 (+)
A/J	MGP_AJ_G0033352	protein coding gene	Chr8:10050391-10099528 (+)
AKR/J	MGP_AKRJ_G0033283	protein coding gene	Chr8:10319245-10364561 (+)
BALB/cJ	MGP_BALBcJ_G0033353	protein coding gene	Chr8:10190864-10233464 (+)
C3H/HeJ	MGP_C3HHeJ_G0033066	protein coding gene	Chr8:10527944-10579135 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033865	protein coding gene	Chr8:10789667-10835475 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030834	protein coding gene	Chr8:9560109-9603736 (+)
CAST/EiJ	MGP_CASTEiJ_G0032388	protein coding gene	Chr8:10287349-10332201 (+)
CBA/J	MGP_CBAJ_G0033039	protein coding gene	Chr8:11237121-11285687 (+)
DBA/2J	MGP_DBA2J_G0033192	protein coding gene	Chr8:10008110-10050413 (+)
FVB/NJ	MGP_FVBNJ_G0033141	protein coding gene	Chr8:10016001-10061789 (+)
LP/J	MGP_LPJ_G0033286	protein coding gene	Chr8:10344123-10388017 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033175	protein coding gene	Chr8:11493370-11536368 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033882	protein coding gene	Chr8:10385646-10429006 (+)
PWK/PhJ	MGP_PWKPhJ_G0032101	protein coding gene	Chr8:10053859-10099113 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031943	protein coding gene	Chr8:10277442-10323541 (+)
WSB/EiJ	MGP_WSBEiJ_G0032504	protein coding gene	Chr8:10416760-10462389 (+)

Human Ortholog

CUL4A, cullin 4A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CUL4A, cullin 4A
Links

HGNC:2554

NCBI Gene ID: 8451

neXtProt AC: NX_Q13619

UniProt: Q13619
Chr Location

13q34; chr13:113208193-113267108 (+) GRCh38

MGI Vertebrate Homology

Cul4a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CUL4A
Gene Tree

Cul4a

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Phenotype Summary

59 phenotypes from 6 alleles in 7 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

2
Gene trapped

2
Targeted

9
Genomic Mutations

1 involving Cul4a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one knock-out allele exhibit reduced female fertility, male infertility, impaired spermatogenesis, and impaired DNA repair.

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All GO Annotations

54
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

841
Tissues

66
cDNA Data

119
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cul4a

ZFIN cul4a

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All Sequences

76
RefSeq

6
UniProt

9
CCDS

CCDS52485.1

Ensembl

ENSMUSG00000031446 (Evidence)
NCBI Gene

99375

			Length	Strain/Species	Flank
genomic	99375	NCBI Gene Model \| MGI Sequence Detail	42318	C57BL/6J	± kb
transcript	NM_146207	RefSeq \| MGI Sequence Detail	3726	C57BL/6
polypeptide	Q3TCH7	UniProt \| EBI \| MGI Sequence Detail	759	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000006049 cullin-4A

(term hierarchy)
InterPro Domains

IPR045093 Cullin

IPR016157 Cullin, conserved site

IPR016158 Cullin homology domain

IPR036317 Cullin homology domain superfamily

IPR001373 Cullin, N-terminal

IPR019559 Cullin protein, neddylation domain

IPR016159 Cullin repeat-like-containing domain superfamily

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

Q3TCH7 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 120

cDNA 119

Primer pair 1

Microarray probesets 5

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MGI:2139358

Summaries

All 74

Developmental Gene Expression 10

Gene Ontology 18

Phenotypes 23
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cul4a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76356	Chr8:13155618-13155627 (+)	0 bp
Tssr76357	Chr8:13155647-13155676 (+)	39 bp
Tssr76358	Chr8:13155715-13155764 (+)	117 bp
Tssr76359	Chr8:13155777-13155788 (+)	160 bp
Tssr2496	Chr8:13188661-13188668 (+)	33,042 bp
Tssr76360	Chr8:13190062-13190081 (+)	34,449 bp
Tssr76361	Chr8:13190128-13190149 (+)	34,516 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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