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Smc6 Gene Detail
Summary
  • Symbol
    Smc6
  • Name
    structural maintenance of chromosomes 6
  • Synonyms
    2810489L22Rik, 3830418C19Rik, Smc6l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914491
    NCBI Gene: 67241
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:11315887-11369786 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 5.58 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1395 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914491
 protein coding gene Chr12:11315887-11369786 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019599
 protein coding gene Chr12:8457641-8515008 (+)
A/J MGP_AJ_G0019566
 protein coding gene Chr12:8149671-8205694 (+)
AKR/J MGP_AKRJ_G0019536
 protein coding gene Chr12:8684384-8745656 (+)
BALB/cJ MGP_BALBcJ_G0019541
 protein coding gene Chr12:8338265-8395094 (+)
C3H/HeJ MGP_C3HHeJ_G0019347
 protein coding gene Chr12:8483121-8539132 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019990
 protein coding gene Chr12:8750167-8803920 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017617
 protein coding gene Chr12:7909090-7973359 (+)
CAST/EiJ MGP_CASTEiJ_G0018903
 protein coding gene Chr12:8443129-8500650 (+)
CBA/J MGP_CBAJ_G0019318
 protein coding gene Chr12:9363359-9425501 (+)
DBA/2J MGP_DBA2J_G0019431
 protein coding gene Chr12:8117769-8172832 (+)
FVB/NJ MGP_FVBNJ_G0019422
 protein coding gene Chr12:8064907-8120088 (+)
LP/J MGP_LPJ_G0019502
 protein coding gene Chr12:8513905-8571686 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019455
 protein coding gene Chr12:9187981-9248059 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020029
 protein coding gene Chr12:8359829-8417195 (+)
PWK/PhJ MGP_PWKPhJ_G0018669
 protein coding gene Chr12:8214221-8269632 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018459
 protein coding gene Chr12:8440823-8506653 (+)
WSB/EiJ MGP_WSBEiJ_G0018954
 protein coding gene Chr12:8432273-8490501 (+)



Homology
more
  • Human Ortholog
    SMC6, structural maintenance of chromosomes 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMC6, structural maintenance of chromosomes 6
  • Synonyms
    hSMC6, SMC-6, SMC6L1
  • Links
    NCBI Gene ID: 79677
    neXtProt AC: NX_Q96SB8
    UniProt: Q96SB8

  • Chr Location
    2p24.2; chr2:17663812-17800242 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit poor embryonic development and embryonic lethality by E105. Mice homozygous for a hypomorphic allele exhibit decreased body weight and weight, decreased litter size and partial lethality. Mice homozygous for a point mutation exhibit a milder phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    7
  • cDNA Data
    24
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67241 NCBI Gene Model | MGI Sequence Detail 53900 C57BL/6J ±  kb
    transcript NM_025695 RefSeq | MGI Sequence Detail 5603 C57BL/6  
    polypeptide Q924W5 UniProt | EBI | MGI Sequence Detail 1097 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000015275 structural maintenance of chromosomes protein 6
      (term hierarchy)
    • InterPro Domains
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR038729 Rad50/SbcC-type AAA domain
    • GlyGen
      Q924W5 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1913919, MGI:2144945, MGI:2145054
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory