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Mtarc2 Gene Detail
Summary
  • Symbol
    Mtarc2
  • Name
    mitochondrial amidoxime reducing component 2
  • Synonyms
    2810484M10Rik, Marc2, Mosc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914497
    NCBI Gene: 67247
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:184545265-184578648 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 89.12 cM, cytoband H4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1222 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914497
 protein coding gene Chr1:184545263-184579266 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016910
 protein coding gene Chr1:191506210-191544439 (-)
A/J MGP_AJ_G0016889
 protein coding gene Chr1:183691244-183726880 (-)
AKR/J MGP_AKRJ_G0016854
 protein coding gene Chr1:189107794-189141432 (-)
BALB/cJ MGP_BALBcJ_G0016847
 protein coding gene Chr1:184328274-184360628 (-)
C3H/HeJ MGP_C3HHeJ_G0016671
 protein coding gene Chr1:189945748-189983473 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017310
 protein coding gene Chr1:197626473-197663514 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015017
 protein coding gene Chr1:174687040-174720741 (-)
CAST/EiJ MGP_CASTEiJ_G0016254
 protein coding gene Chr1:189369821-189403189 (-)
CBA/J MGP_CBAJ_G0016645
 protein coding gene Chr1:204993547-205028816 (-)
DBA/2J MGP_DBA2J_G0016751
 protein coding gene Chr1:182453186-182485152 (-)
FVB/NJ MGP_FVBNJ_G0016747
 protein coding gene Chr1:180551441-180584048 (-)
LP/J MGP_LPJ_G0016826
 protein coding gene Chr1:192665058-192700671 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016779
 protein coding gene Chr1:211903842-211937170 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017347
 protein coding gene Chr1:188957628-188991457 (-)
PWK/PhJ MGP_PWKPhJ_G0016041
 protein coding gene Chr1:181649497-181686196 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015817
 protein coding gene Chr1:187924664-187957801 (-)
WSB/EiJ MGP_WSBEiJ_G0016316
 protein coding gene Chr1:189135391-189170262 (-)



Homology
more
  • Human Ortholog
    MTARC2, mitochondrial amidoxime reducing component 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTARC2, mitochondrial amidoxime reducing component 2
  • Synonyms
    MARC2, MOSC2
  • Links
    NCBI Gene ID: 54996
    neXtProt AC: NX_Q969Z3
    UniProt: Q969Z3

  • Chr Location
    1q41; chr1:220748225-220784815 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null allele exhibit rapidly progressive hind limb paralysis at 7-10 weeks of age and young females have decreased weight and body fat mass.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    137
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000073481 Ensembl Gene Model | MGI Sequence Detail 33384 C57BL/6J ±  kb
    transcript ENSMUST00000068725 Ensembl | MGI Sequence Detail 1917 Not Applicable  
    polypeptide ENSMUSP00000066715 Ensembl | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000010528 mitochondrial amidoxime reducing component 2
      (term hierarchy)
    • EC
      1.7.-.-
    • InterPro Domains
      IPR005302 Molybdenum cofactor sulfurase, C-terminal
      IPR005303 Molybdenum cofactor sulfurase, middle domain
      IPR011037 Pyruvate kinase-like, insert domain superfamily
    • GlyGen
      Q922Q1 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 137
      cDNA 137

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:6368866
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:346201 Smagris E, et al., Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse. PLoS Genet. 2024 Mar;20(3):e1011179
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory