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Cap2 Gene Detail
Summary
  • Symbol
    Cap2
  • Name
    cyclase associated actin cytoskeleton regulatory protein 2
  • Synonyms
    2810452G09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914502
    NCBI Gene: 67252
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:46655379-46803757 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 23.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4060 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914502
 protein coding gene Chr13:46655324-46803757 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020513
 protein coding gene Chr13:45270542-45423248 (+)
A/J MGP_AJ_G0020467
 protein coding gene Chr13:43702943-43850608 (+)
AKR/J MGP_AKRJ_G0020444
 protein coding gene Chr13:44904028-45055596 (+)
BALB/cJ MGP_BALBcJ_G0020463
 protein coding gene Chr13:43934440-44055418 (+)
C3H/HeJ MGP_C3HHeJ_G0020262
 protein coding gene Chr13:44772854-44922926 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020896
 protein coding gene Chr13:46654860-46808839 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018482
 protein coding gene Chr13:41743846-41884575 (+)
CAST/EiJ MGP_CASTEiJ_G0019777
 protein coding gene Chr13:44722471-44851328 (+)
CBA/J MGP_CBAJ_G0020223
 protein coding gene Chr13:48607489-48756841 (+)
DBA/2J MGP_DBA2J_G0020345
 protein coding gene Chr13:43262475-43406855 (+)
FVB/NJ MGP_FVBNJ_G0020324
 protein coding gene Chr13:42804177-42924968 (+)
LP/J MGP_LPJ_G0020420
 protein coding gene Chr13:45502647-45655186 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020353
 protein coding gene Chr13:48431764-48581053 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020939
 protein coding gene Chr13:44583981-44735011 (+)
PWK/PhJ MGP_PWKPhJ_G0019533
 protein coding gene Chr13:43385360-43532376 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019361
 protein coding gene Chr13:43280943-43406108 (+)
WSB/EiJ MGP_WSBEiJ_G0019839
 protein coding gene Chr13:44913626-45064004 (+)



Homology
more
  • Human Ortholog
    CAP2, cyclase associated actin cytoskeleton regulatory protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAP2, cyclase associated actin cytoskeleton regulatory protein 2
  • Synonyms
    CMD2I
  • Links
    NCBI Gene ID: 10486
    neXtProt AC: NX_P40123
    UniProt: P40123

  • Chr Location
    6p22.3; chr6:17393595-17557780 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cap2 mouse models; 1 with human CAP2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 4 alleles in 4 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are smaller, prone to eye infections and show microphthalmia, cardiac conduction defects and dilated cardiomyopathy, predominantly in males. Males are underrepresented at weaning and ~70% die suddenly by 12 weeks of age, whereas females survive at nearly expected levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    46
  • cDNA Data
    31
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67252 NCBI Gene Model | MGI Sequence Detail 148379 C57BL/6J ±  kb
    transcript NM_026056 RefSeq | MGI Sequence Detail 3673 C57BL/6  
    polypeptide Q9CYT6 UniProt | EBI | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005007 adenylyl cyclase-associated protein 2
      (term hierarchy)
    • InterPro Domains
      IPR001837 Adenylate cyclase-associated CAP
      IPR013912 Adenylate cyclase-associated CAP, C-terminal
      IPR036223 Adenylate cyclase-associated CAP, C-terminal superfamily
      IPR013992 Adenylate cyclase-associated CAP, N-terminal
      IPR036222 Adenylate cyclase-associated CAP, N-terminal domain superfamily
      IPR028417 CAP, conserved site, C-terminal
      IPR018106 CAP, conserved site, N-terminal
      IPR006599 CARP motif
      IPR017901 C-CAP/cofactor C-like domain
      IPR016098 Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal
    • GlyGen
      Q9CYT6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 32
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145392
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:351187 Khudayberdiev S, et al., The actin-binding protein CAP1 represses MRTF-SRF-dependent gene expression in mouse cerebral cortex. Sci Signal. 2024 May 7;17(835):eadj0032
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory