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Zswim6 Gene Detail
Summary
  • Symbol
    Zswim6
  • Name
    zinc finger SWIM-type containing 6
  • Synonyms
    2900036G02Rik, mKIAA1577
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914513
    NCBI Gene: 67263
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:107861152-108026598 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 59.39 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4163 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914513
 protein coding gene Chr13:107861152-108026598 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020921
 protein coding gene Chr13:109978637-110155091 (-)
A/J MGP_AJ_G0020871
 protein coding gene Chr13:105668238-105835515 (-)
AKR/J MGP_AKRJ_G0020846
 protein coding gene Chr13:108878841-109041889 (-)
BALB/cJ MGP_BALBcJ_G0020871
 protein coding gene Chr13:106385030-106553432 (-)
C3H/HeJ MGP_C3HHeJ_G0020660
 protein coding gene Chr13:108642255-108815749 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021306
 protein coding gene Chr13:113294180-113473919 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018875
 protein coding gene Chr13:101102270-101266149 (-)
CAST/EiJ MGP_CASTEiJ_G0020179
 protein coding gene Chr13:108176592-108345483 (-)
CBA/J MGP_CBAJ_G0020622
 protein coding gene Chr13:117661291-117838515 (-)
DBA/2J MGP_DBA2J_G0020746
 protein coding gene Chr13:105435862-105601179 (-)
FVB/NJ MGP_FVBNJ_G0020728
 protein coding gene Chr13:104080367-104246567 (-)
LP/J MGP_LPJ_G0020820
 protein coding gene Chr13:110058626-110226802 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020756
 protein coding gene Chr13:118093193-118265995 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021344
 protein coding gene Chr13:108322252-108494452 (-)
PWK/PhJ MGP_PWKPhJ_G0019932
 protein coding gene Chr13:104111842-104278188 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019754
 protein coding gene Chr13:104589633-104767014 (-)
WSB/EiJ MGP_WSBEiJ_G0020237
 protein coding gene Chr13:108874097-109047268 (-)



Homology
more
  • Human Ortholog
    ZSWIM6, zinc finger SWIM-type containing 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZSWIM6, zinc finger SWIM-type containing 6
  • Synonyms
    AFND, NEDMAGA
  • Links
    NCBI Gene ID: 57688
    neXtProt AC: NX_Q9HCJ5
    UniProt: Q9HCJ5

  • Chr Location
    5q12.1; chr5:61332258-61546172 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ZSWIM6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial postnatal lethality, decreased striatal volume, abnormal medium spiny neuron morphology, and altered motor control including hyperactivity, impaired rotarod performance, repetitive movements, and behavioral hyperresponsiveness to amphetamine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    46
  • cDNA Data
    35
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      43
    • RefSeq
      2
    • UniProt
      5
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67263 NCBI Gene Model | MGI Sequence Detail 165447 C57BL/6J ±  kb
    transcript NM_145456 RefSeq | MGI Sequence Detail 5457 C57BL/6  
    polypeptide Q80TB7 UniProt | EBI | MGI Sequence Detail 1207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 35
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory