Slc39a10 MGI Mouse Gene Detail - MGI:1914515 - solute carrier family 39 (zinc transporter), member 10

Symbol

Slc39a10
Name

solute carrier family 39 (zinc transporter), member 10
Synonyms

2900042E17Rik, mKIAA1265, Zip10

Feature Type

protein coding gene
IDs

MGI:1914515
NCBI Gene: 227059
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr1:46846704-46932012 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 24.07 cM
Mapping Data

2 experiments

SNPs within 2kb

2324 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914515	protein coding gene	Chr1:46846704-46964952 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016000	protein coding gene	Chr1:46130222-46216229 (-)
A/J	MGP_AJ_G0015982	protein coding gene	Chr1:44605803-44699866 (-)
AKR/J	MGP_AKRJ_G0015938	protein coding gene	Chr1:45542280-45637594 (-)
BALB/cJ	MGP_BALBcJ_G0015939	protein coding gene	Chr1:44394077-44480965 (-)
C3H/HeJ	MGP_C3HHeJ_G0015771	protein coding gene	Chr1:45910162-45993888 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016390	protein coding gene	Chr1:48068517-48161201 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014134	protein coding gene	Chr1:46636442-46721826 (+)
CAST/EiJ	MGP_CASTEiJ_G0015352	protein coding gene	Chr1:45312271-45410508 (-)
CBA/J	MGP_CBAJ_G0015742	protein coding gene	Chr1:49343263-49439376 (-)
DBA/2J	MGP_DBA2J_G0015843	protein coding gene	Chr1:43904927-43991311 (-)
FVB/NJ	MGP_FVBNJ_G0015845	protein coding gene	Chr1:43424337-43505341 (-)
LP/J	MGP_LPJ_G0015913	protein coding gene	Chr1:46539848-46651898 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015865	protein coding gene	Chr1:51604507-51712240 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016438	protein coding gene	Chr1:45599090-45692817 (-)
PWK/PhJ	MGP_PWKPhJ_G0015138	protein coding gene	Chr1:43796165-43880188 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014918	protein coding gene	Chr1:45460979-45540146 (-)
WSB/EiJ	MGP_WSBEiJ_G0015414	protein coding gene	Chr1:45419691-45500114 (-)

Human Ortholog

SLC39A10, solute carrier family 39 member 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC39A10, solute carrier family 39 member 10
Synonyms

LZT-Hs2, ZIP10
Links

HGNC:20861

NCBI Gene ID: 57181

neXtProt AC: NX_Q9ULF5

UniProt: Q9ULF5
Chr Location

2q32.3; chr2:195575977-195737702 (+) GRCh38

MGI Vertebrate Homology

Slc39a10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC39A10
Gene Tree

Slc39a10

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Phenotype Summary

31 phenotypes from 2 alleles in 4 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

21
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Slc39a10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with conditional loss of function display defects in cellular proliferation and differentiation.

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All GO Annotations

26
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

840
Tissues

33
cDNA Data

12
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc39a10

ZFIN slc39a10

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All Sequences

57
RefSeq

12
UniProt

3
CCDS

CCDS14936.1

Ensembl

ENSMUSG00000025986 (Evidence)
NCBI Gene

227059

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025986	Ensembl Gene Model \| MGI Sequence Detail	85309	C57BL/6J	± kb
transcript	ENSMUST00000027131	Ensembl \| MGI Sequence Detail	5498	Not Applicable
polypeptide	ENSMUSP00000027131	Ensembl \| MGI Sequence Detail	833	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015124 zinc transporter ZIP10

(term hierarchy)
InterPro Domains

IPR003689 Zinc/iron permease

IPR050799 Zinc Iron Protein (ZIP) Transporter
GlyGen

Q6P5F6 6 sites, 13 N-linked glycans (5 sites), 1 O-linked glycan (1 site)

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All nucleic 15

Genomic 1

cDNA 12

Primer pair 2

Microarray probesets 5

Summaries

All 52

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 24
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc39a10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11556	Chr1:46932292-46932296 (-)	-282 bp
Tssr76	Chr1:46932239-46932244 (-)	-230 bp
Tssr11555	Chr1:46932209-46932226 (-)	-206 bp
Tssr11554	Chr1:46932182-46932191 (-)	-175 bp
Tssr11553	Chr1:46927301-46927313 (-)	4,705 bp
Tssr11552	Chr1:46927293-46927300 (-)	4,715 bp
Tssr11551	Chr1:46927245-46927260 (-)	4,759 bp
Tssr11550	Chr1:46893212-46893239 (-)	38,786 bp
Tssr11549	Chr1:46893043-46893076 (-)	38,952 bp
Tssr11548	Chr1:46893009-46893022 (-)	38,996 bp
Tssr11547	Chr1:46892769-46892790 (-)	39,232 bp
Tssr11546	Chr1:46892743-46892765 (-)	39,258 bp
Tssr11545	Chr1:46892642-46892731 (-)	39,325 bp
Tssr11544	Chr1:46892583-46892602 (-)	39,419 bp
Tssr75	Chr1:46891942-46891955 (-)	40,063 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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