Socs4 MGI Mouse Gene Detail - MGI:1914546 - suppressor of cytokine signaling 4

Symbol

Socs4
Name

suppressor of cytokine signaling 4
Synonyms

3110032M18Rik, A730004F22Rik, Socs7

Feature Type

protein coding gene
IDs

MGI:1914546
NCBI Gene: 67296
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr14:47514388-47533559 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 24.60 cM
Mapping Data

2 experiments

SNPs within 2kb

383 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914546	protein coding gene	Chr14:47514377-47533559 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021220	protein coding gene	Chr14:41011979-41033082 (+)
A/J	MGP_AJ_G0021167	protein coding gene	Chr14:39773937-39793253 (+)
AKR/J	MGP_AKRJ_G0021145	protein coding gene	Chr14:41317304-41337675 (+)
BALB/cJ	MGP_BALBcJ_G0021171	protein coding gene	Chr14:39827301-39847229 (+)
C3H/HeJ	MGP_C3HHeJ_G0020954	protein coding gene	Chr14:41107890-41129580 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021605	protein coding gene	Chr14:42759602-42780320 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019164	protein coding gene	Chr14:39133378-39153409 (+)
CAST/EiJ	MGP_CASTEiJ_G0020479	protein coding gene	Chr14:38228736-38249516 (+)
CBA/J	MGP_CBAJ_G0020920	protein coding gene	Chr14:44112754-44138021 (+)
DBA/2J	MGP_DBA2J_G0021043	protein coding gene	Chr14:39667278-39686400 (+)
FVB/NJ	MGP_FVBNJ_G0021028	protein coding gene	Chr14:39408427-39427905 (+)
LP/J	MGP_LPJ_G0021113	protein coding gene	Chr14:41292924-41315514 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021053	protein coding gene	Chr14:43475306-43495021 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021638	protein coding gene	Chr14:40866266-40886098 (+)
PWK/PhJ	MGP_PWKPhJ_G0020228	protein coding gene	Chr14:36544311-36563593 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020052	protein coding gene	Chr14:36990851-37010891 (+)
WSB/EiJ	MGP_WSBEiJ_G0020535	protein coding gene	Chr14:40963997-40984053 (+)

Human Ortholog

SOCS4, suppressor of cytokine signaling 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SOCS4, suppressor of cytokine signaling 4
Synonyms

SOCS7
Links

HGNC:19392

NCBI Gene ID: 122809

neXtProt AC: NX_Q8WXH5

UniProt: Q8WXH5
Chr Location

14q22.3; chr14:55027230-55049489 (+) GRCh38

MGI Vertebrate Homology

Socs4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SOCS4
Gene Tree

Socs4

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Phenotype Summary

20 phenotypes from 1 allele in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (ENU)

1
Chemically induced (other)

1
Gene trapped

12
Targeted

2
Genomic Mutations

1 involving Socs4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygosity for a knockout allele leads to increased susceptibility to influenza-virus-induced morbidity and mortality.

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All GO Annotations

6
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

830
Tissues

18
cDNA Data

14
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase socs4

ZFIN socs4

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All Sequences

48
RefSeq

2
UniProt

5
CCDS

CCDS26985.1

Ensembl

ENSMUSG00000048379 (Evidence)
NCBI Gene

67296

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048379	Ensembl Gene Model \| MGI Sequence Detail	19172	C57BL/6J	± kb
transcript	ENSMUST00000065562	Ensembl \| MGI Sequence Detail	6877	Not Applicable
polypeptide	ENSMUSP00000066031	Ensembl \| MGI Sequence Detail	436	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015395 suppressor of cytokine signaling 4

(term hierarchy)
InterPro Domains

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR035864 SOCS4, SH2 domain

IPR022252 SOCS4/SOCS5 domain

IPR037342 SOCS4, SOCS box domain

IPR001496 SOCS box domain

IPR036036 SOCS box-like domain superfamily

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 7

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MGI:2145633, MGI:2145722, MGI:2145724

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 12
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Socs4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125258	Chr14:47514367-47514393 (+)	-8 bp
Tssr125259	Chr14:47514447-47514466 (+)	69 bp
Tssr125260	Chr14:47514497-47514502 (+)	112 bp
Tssr4386	Chr14:47514591-47514600 (+)	208 bp
Tssr125261	Chr14:47524615-47524617 (+)	10,228 bp
Tssr125262	Chr14:47529410-47529423 (+)	15,029 bp
Tssr125263	Chr14:47529763-47529767 (+)	15,377 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24