Gpx7 MGI Mouse Gene Detail - MGI:1914555 - glutathione peroxidase 7

Symbol

Gpx7
Name

glutathione peroxidase 7
Synonyms

3110050F08Rik, GPX6

Feature Type

protein coding gene
IDs

MGI:1914555
NCBI Gene: 67305
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:108257414-108263910 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 50.50 cM
Mapping Data

2 experiments

SNPs within 2kb

258 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914555	protein coding gene	Chr4:108257414-108264158 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028554	protein coding gene	Chr4:109133919-109142121 (-)
A/J	MGP_AJ_G0028517	protein coding gene	Chr4:105208776-105215331 (-)
AKR/J	MGP_AKRJ_G0028464	protein coding gene	Chr4:107823866-107830417 (-)
BALB/cJ	MGP_BALBcJ_G0028536	protein coding gene	Chr4:105407791-105414356 (-)
C3H/HeJ	MGP_C3HHeJ_G0028250	protein coding gene	Chr4:108545049-108551831 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028976	protein coding gene	Chr4:113048084-113054640 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026267	protein coding gene	Chr4:100494561-100501040 (-)
CAST/EiJ	MGP_CASTEiJ_G0027686	protein coding gene	Chr4:106406237-106414599 (-)
CBA/J	MGP_CBAJ_G0028219	protein coding gene	Chr4:116762046-116770331 (-)
DBA/2J	MGP_DBA2J_G0028367	protein coding gene	Chr4:104835445-104842006 (-)
FVB/NJ	MGP_FVBNJ_G0028335	protein coding gene	Chr4:103706988-103713935 (-)
LP/J	MGP_LPJ_G0028468	protein coding gene	Chr4:109363700-109370284 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028361	protein coding gene	Chr4:121962900-121970843 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029012	protein coding gene	Chr4:108064464-108071021 (-)
PWK/PhJ	MGP_PWKPhJ_G0027412	protein coding gene	Chr4:103099913-103106622 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027236	protein coding gene	Chr4:105404355-105410895 (-)
WSB/EiJ	MGP_WSBEiJ_G0027767	protein coding gene	Chr4:108245243-108251789 (-)

Human Ortholog

GPX7, glutathione peroxidase 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPX7, glutathione peroxidase 7
Synonyms

CL683, GPX6, GPx-7, GSHPx-7, NPGPx
Links

HGNC:4559

NCBI Gene ID: 2882

neXtProt AC: NX_Q96SL4

UniProt: Q96SL4
Chr Location

1p32.3; chr1:52602371-52609051 (+) GRCh38

MGI Vertebrate Homology

Gpx7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPX7
Protein SuperFamily

Glutathion_perox
Gene Tree

Gpx7

Diseases

2 with human GPX7 associations

				Human Disease	Mouse Models
				Barrett's adenocarcinoma IDs Barrett's adenocarcinoma DOID:7941 NCI:C7027 UMLS_CUI:C1332460
				Barrett's esophagus IDs Barrett's esophagus DOID:9206 EFO:0000280 ICD10CM:K22.7 ICD9CM:530.85 MESH:D001471 NCI:C2891 OMIM:614266 UMLS_CUI:C0004763

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

25 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Gpx7
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased cellular sensitivity to oxidative stress, premature death, systemic disease and increased tumor incidence.

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All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1167
Tissues

185
cDNA Data

34
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpx7

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All Sequences

37
RefSeq

2
UniProt

4
CCDS

CCDS18450.1

Ensembl

ENSMUSG00000028597 (Evidence)
NCBI Gene

67305

			Length	Strain/Species	Flank
genomic	67305	NCBI Gene Model \| MGI Sequence Detail	6497	C57BL/6J	± kb
transcript	NM_024198	RefSeq \| MGI Sequence Detail	1214	C57BL/6
polypeptide	Q99LJ6	UniProt \| EBI \| MGI Sequence Detail	186	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008216 glutathione peroxidase 7

(term hierarchy)
EC

1.11.1.9
InterPro Domains

IPR000889 Glutathione peroxidase

IPR029759 Glutathione peroxidase active site

IPR029760 Glutathione peroxidase conserved site

IPR013376 Glutathione peroxidase Gpx7, putative

IPR036249 Thioredoxin-like superfamily

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All nucleic 36

cDNA 34

Primer pair 2

Microarray probesets 3

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MGI:2140249

Summaries

All 52

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 17
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gpx7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr42724	Chr4:108263873-108263942 (-)	2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24