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Mrpl46 Gene Detail
Summary
  • Symbol
    Mrpl46
  • Name
    mitochondrial ribosomal protein L46
  • Synonyms
    3110052F15Rik, LIECG2, P2ECSL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914558
    NCBI Gene: 67308
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:78425089-78432837 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 44.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    354 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914558
 protein coding gene Chr7:78424984-78433279 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032378
 protein coding gene Chr7:80606554-80614911 (-)
A/J MGP_AJ_G0032357
 protein coding gene Chr7:78771023-78779319 (-)
AKR/J MGP_AKRJ_G0032293
 protein coding gene Chr7:80462406-80470700 (-)
BALB/cJ MGP_BALBcJ_G0032369
 protein coding gene Chr7:78469208-78477792 (-)
C3H/HeJ MGP_C3HHeJ_G0032082
 protein coding gene Chr7:81123424-81132335 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032861
 protein coding gene Chr7:83779402-83788786 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029869
 protein coding gene Chr7:81332778-81341276 (-)
CAST/EiJ MGP_CASTEiJ_G0031410
 protein coding gene Chr7:71964525-71972931 (-)
CBA/J MGP_CBAJ_G0032048
 protein coding gene Chr7:86542949-86552087 (-)
DBA/2J MGP_DBA2J_G0032203
 protein coding gene Chr7:77364030-77373201 (-)
FVB/NJ MGP_FVBNJ_G0032158
 protein coding gene Chr7:77262850-77271152 (-)
LP/J MGP_LPJ_G0032284
 protein coding gene Chr7:81855021-81863311 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032195
 protein coding gene Chr7:86817551-86826719 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032879
 protein coding gene Chr7:79899465-79908916 (-)
PWK/PhJ MGP_PWKPhJ_G0031130
 protein coding gene Chr7:70506497-70515177 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030971
 protein coding gene Chr7:66886031-66894254 (-)
WSB/EiJ MGP_WSBEiJ_G0031528
 protein coding gene Chr7:80220083-80229368 (-)



Homology
more
  • Human Ortholog
    MRPL46, mitochondrial ribosomal protein L46
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRPL46, mitochondrial ribosomal protein L46
  • Synonyms
    C15orf4, LIECG2, mL46, P2ECSL
  • Links
    NCBI Gene ID: 26589
    neXtProt AC: NX_Q9H2W6
    UniProt: Q9H2W6

  • Chr Location
    15q25.3; chr15:88459477-88467390 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Mrpl46
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    10 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    13
  • cDNA Data
    52
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67308 NCBI Gene Model | MGI Sequence Detail 7749 C57BL/6J ±  kb
transcript NM_023331 RefSeq | MGI Sequence Detail 1173 Not Specified  
polypeptide Q9EQI8 UniProt | EBI | MGI Sequence Detail 283 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010607 large ribosomal subunit protein mL46
    (term hierarchy)
  • InterPro Domains
    IPR040008 Large ribosomal subunit protein mL46
    IPR021757 Large ribosomal subunit protein mL46, N-terminal
    IPR033650 Large ribosomal subunit protein mL46, NUDIX domain
    IPR015797 NUDIX hydrolase-like domain superfamily
  • GlyGen
    Q9EQI8 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 53
    cDNA 52
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142340
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:297050 Cheong A, et al., Expression analysis of mammalian mitochondrial ribosomal protein genes. Gene Expr Patterns. 2020 Sep 25;38:119147
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory