Stk35 MGI Mouse Gene Detail - MGI:1914583 - serine/threonine kinase 35

Symbol

Stk35
Name

serine/threonine kinase 35
Synonyms

1700054C12Rik, CLIK1, CLP-36 interacting kinase

Feature Type

protein coding gene
IDs

MGI:1914583
NCBI Gene: 67333
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr2:129642437-129674207 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 63.19 cM
Mapping Data

1 experiment

SNPs within 2kb

720 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914583	protein coding gene	Chr2:129642437-129674207 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026492	protein coding gene	Chr2:133213390-133246960 (+)
A/J	MGP_AJ_G0026456	protein coding gene	Chr2:127808220-127839990 (+)
AKR/J	MGP_AKRJ_G0026431	protein coding gene	Chr2:131433251-131467234 (+)
BALB/cJ	MGP_BALBcJ_G0026468	protein coding gene	Chr2:128088934-128120886 (+)
C3H/HeJ	MGP_C3HHeJ_G0026211	protein coding gene	Chr2:131958358-131990417 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026913	protein coding gene	Chr2:137358125-137395833 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024290	protein coding gene	Chr2:122598864-122629925 (+)
CAST/EiJ	MGP_CASTEiJ_G0025672	protein coding gene	Chr2:132195019-132227916 (+)
CBA/J	MGP_CBAJ_G0026191	protein coding gene	Chr2:142446062-142478952 (+)
DBA/2J	MGP_DBA2J_G0026325	protein coding gene	Chr2:127194718-127226295 (+)
FVB/NJ	MGP_FVBNJ_G0026289	protein coding gene	Chr2:125842353-125874243 (+)
LP/J	MGP_LPJ_G0026430	protein coding gene	Chr2:133476609-133508532 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026309	protein coding gene	Chr2:146317703-146349828 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026968	protein coding gene	Chr2:131474431-131506327 (+)
PWK/PhJ	MGP_PWKPhJ_G0025408	protein coding gene	Chr2:126772717-126806632 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025210	protein coding gene	Chr2:130595798-130627642 (+)
WSB/EiJ	MGP_WSBEiJ_G0025746	protein coding gene	Chr2:132401591-132434497 (+)

Human Ortholog

STK35, serine/threonine kinase 35

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STK35, serine/threonine kinase 35
Synonyms

CLIK1, STK35L1
Links

HGNC:16254

NCBI Gene ID: 140901

neXtProt AC: NX_Q8TDR2

UniProt: Q8TDR2
Chr Location

20p13; chr20:2101827-2177038 (+) GRCh38

MGI Vertebrate Homology

Stk35 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: STK35
Gene Tree

Stk35

less

Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
21 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Stk35
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal gametogenesis, eye defects and partial lethality during organogenesis.

less

All GO Annotations

33
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

858
Tissues

24
cDNA Data

51
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stk35, stk35l

less

All Sequences

43
RefSeq

4
UniProt

2
CCDS

CCDS16731.2, CCDS16732.2

Ensembl

ENSMUSG00000037885 (Evidence)
NCBI Gene

67333

			Length	Strain/Species	Flank
genomic	67333	NCBI Gene Model \| MGI Sequence Detail	31771	C57BL/6J	± kb
transcript	NM_183262	RefSeq \| MGI Sequence Detail	6204	C57BL/6
polypeptide	Q80ZW0	UniProt \| EBI \| MGI Sequence Detail	539	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000015752 serine/threonine-protein kinase 35

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR050339 Cell Cycle and Stress Response Kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

less

All nucleic 57

cDNA 54

Primer pair 3

Microarray probesets 4

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Stk35:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20180	Chr2:129642204-129642213 (+)	-228 bp
Tssr20181	Chr2:129642215-129642239 (+)	-210 bp
Tssr20182	Chr2:129642371-129642446 (+)	-28 bp
Tssr20183	Chr2:129642502-129642561 (+)	95 bp
Tssr20184	Chr2:129642588-129642618 (+)	166 bp
Tssr20185	Chr2:129642631-129642648 (+)	203 bp
Tssr20186	Chr2:129642651-129642660 (+)	219 bp
Tssr20187	Chr2:129642662-129642685 (+)	237 bp
Tssr20188	Chr2:129643312-129643316 (+)	877 bp
Tssr20189	Chr2:129643486-129643525 (+)	1,069 bp
Tssr20190	Chr2:129673989-129673995 (+)	31,555 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24