Ascl4 MGI Mouse Gene Detail - MGI:1914591 - achaete-scute family bHLH transcription factor 4

Symbol

Ascl4
Name

achaete-scute family bHLH transcription factor 4
Synonyms

1700054F16Rik, bHLHa44

Feature Type

protein coding gene
IDs

MGI:1914591
NCBI Gene: 67341
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:85763266-85765513 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 41.80 cM
Mapping Data

1 experiment

SNPs within 2kb

129 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914591	protein coding gene	Chr10:85763266-85782070 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017604	protein coding gene	Chr10:86865839-86889403 (+)
A/J	MGP_AJ_G0017584	protein coding gene	Chr10:83972885-83996726 (+)
AKR/J	MGP_AKRJ_G0017544	protein coding gene	Chr10:86324969-86350628 (+)
BALB/cJ	MGP_BALBcJ_G0017547	protein coding gene	Chr10:84202917-84223048 (+)
C3H/HeJ	MGP_C3HHeJ_G0017370	protein coding gene	Chr10:86357377-86375791 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018004	protein coding gene	Chr10:89821934-89845763 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015688	protein coding gene	Chr10:79802130-79822116 (+)
CAST/EiJ	MGP_CASTEiJ_G0016936	protein coding gene	Chr10:86209380-86233882 (+)
CBA/J	MGP_CBAJ_G0017339	protein coding gene	Chr10:93526013-93554216 (+)
DBA/2J	MGP_DBA2J_G0017446	protein coding gene	Chr10:83088606-83108190 (+)
FVB/NJ	MGP_FVBNJ_G0017439	protein coding gene	Chr10:82357050-82375888 (+)
LP/J	MGP_LPJ_G0017518	protein coding gene	Chr10:87546929-87567085 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017467	protein coding gene	Chr10:95173460-95194437 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018041	protein coding gene	Chr10:86200457-86220109 (+)
PWK/PhJ	MGP_PWKPhJ_G0016717	protein coding gene	Chr10:83094014-83112397 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016506	protein coding gene	Chr10:84842187-84865068 (+)
WSB/EiJ	MGP_WSBEiJ_G0016994	protein coding gene	Chr10:86161369-86179759 (+)

Human Ortholog

ASCL4, achaete-scute family bHLH transcription factor 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASCL4, achaete-scute family bHLH transcription factor 4
Synonyms

ASH-4, bHLHa44, HASH4
Links

HGNC:24311

NCBI Gene ID: 121549

neXtProt AC: NX_Q6XD76

UniProt: Q6XD76
Chr Location

12q23.3; chr12:107774704-107776644 (+) GRCh38

MGI Vertebrate Homology

Ascl4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ASCL4
Gene Tree

Ascl4

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Genomic Mutations

1 involving Ascl4
Incidental Mutations

CvDC
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

6
cDNA Data

3
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ASCL4

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All Sequences

30
RefSeq

2
UniProt

2
CCDS

CCDS59549.1

Ensembl

ENSMUSG00000085111 (Evidence)
NCBI Gene

67341

			Length	Strain/Species	Flank
genomic	67341	NCBI Gene Model \| MGI Sequence Detail	2248	C57BL/6J	± kb
transcript	NM_001163614	RefSeq \| MGI Sequence Detail	2248	C57BL/6
polypeptide	NP_001157086	RefSeq \| MGI Sequence Detail	144	C57BL/6

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UniProt

2 Sequences
InterPro Domains

IPR050283 E-box Binding Transcriptional Regulators

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

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All nucleic 5

cDNA 3

Primer pair 1

Other 1

Summaries

All 31

Developmental Gene Expression 5

Gene Ontology 1

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:350462 Papagno V, et al., Wnt target gene Ascl4 is dispensable for skin appendage development. Int J Dev Biol. 2024 May 13;

TSS for Ascl4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94938	Chr10:85763264-85763272 (+)	2 bp
Tssr3300	Chr10:85763842-85763845 (+)	578 bp
Tssr94939	Chr10:85764946-85764951 (+)	1,683 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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