Larp1b Gene Detail

Summary

• Symbol
  Larp1b
• Name
  La ribonucleoprotein 1B
• Synonyms
  1700108L22Rik, 4933421B21Rik, Larp2

• Feature Type
  protein coding gene
• IDs
  MGI:1914604
  NCBI Gene: 214048
• Alliance
  gene page
• Transcription Start Sites
  11 TSS

Location &
Maps

• Sequence Map
  Chr3:40904263-40994669 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 19.61 cM, cytoband C
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  2352 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914604	protein coding gene	Chr3:40904198-40994669 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027184	protein coding gene	Chr3:38948889-39042579 (+)
A/J	MGP_AJ_G0027144	protein coding gene	Chr3:37997733-38087840 (+)
AKR/J	MGP_AKRJ_G0027113	protein coding gene	Chr3:38718127-38808508 (+)
BALB/cJ	MGP_BALBcJ_G0027156	protein coding gene	Chr3:37769176-37859637 (+)
C3H/HeJ	MGP_C3HHeJ_G0026899	protein coding gene	Chr3:38841370-38933821 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027602	protein coding gene	Chr3:40567554-40658710 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024962	protein coding gene	Chr3:35491763-35593158 (+)
CAST/EiJ	MGP_CASTEiJ_G0026352	protein coding gene	Chr3:38705064-38801307 (+)
CBA/J	MGP_CBAJ_G0026876	protein coding gene	Chr3:41716100-41811407 (+)
DBA/2J	MGP_DBA2J_G0027010	protein coding gene	Chr3:37462722-37554040 (+)
FVB/NJ	MGP_FVBNJ_G0026978	protein coding gene	Chr3:36835365-36925368 (+)
LP/J	MGP_LPJ_G0027122	protein coding gene	Chr3:39686131-39783612 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026996	protein coding gene	Chr3:44178728-44273807 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027661	protein coding gene	Chr3:38584478-38677522 (+)
PWK/PhJ	MGP_PWKPhJ_G0026084	protein coding gene	Chr3:37135608-37230352 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025897	protein coding gene	Chr3:37977103-38073229 (+)
WSB/EiJ	MGP_WSBEiJ_G0026426	protein coding gene	Chr3:38593157-38683637 (+)

Homology

• Human Ortholog
  LARP1B, La ribonucleoprotein 1B

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LARP1B, La ribonucleoprotein 1B
  
• Synonyms
  LARP2
• Links
  HGNC:24704

  NCBI Gene ID: 55132

  neXtProt AC: NX_Q659C4

  UniProt: Q659C4

  
  
• Chr Location
  4q28.2; chr4:128060789-128222931 (+)  GRCh38

---

• MGI Vertebrate Homology
  Larp1b stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: LARP1B
• Gene Tree
  Larp1b
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  10 phenotype references
  

• All Mutations and Alleles
  5
• Endonuclease-mediated
  1
• Radiation induced
  2
• Targeted
  2
• Genomic Mutations
  2 involving Larp1b
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  35 strains or lines available

Expression

• Assay Results
  706
• cDNA Data
  16

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase larp1b

Sequences &
Gene Models

• All Sequences
  89
• RefSeq
  27
• UniProt
  8
• CCDS
  CCDS38423.1, CCDS89623.1

• Ensembl
  ENSMUSG00000025762 (Evidence)
• NCBI Gene
  214048

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000025762	Ensembl Gene Model | MGI Sequence Detail	90407	C57BL/6J
transcript	ENSMUST00000048490	Ensembl | MGI Sequence Detail	2497	Not Applicable
polypeptide	ENSMUSP00000037127	Ensembl | MGI Sequence Detail	541	Not Applicable

Protein
Information

• UniProt
  8 Sequences
• InterPro Domains
  IPR045180 La domain containing protein
  IPR006607 LARP1-like, DM15 repeat
  IPR006630 La-type HTH domain
  IPR036390 Winged helix DNA-binding domain superfamily
  IPR036388 Winged helix-like DNA-binding domain superfamily

Molecular
Reagents

• All nucleic 16

  cDNA 16

  
  

  Microarray probesets 6

Other
Accession IDs

MGI:1918324, MGI:2139606

References

• Summaries
  All 32

  Diseases 1

  Phenotypes 10
• Earliest
  J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Larp1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28976	Chr3:40904216-40904249 (+)	-30 bp
Tssr28977	Chr3:40904253-40904287 (+)	7 bp
Tssr28978	Chr3:40904350-40904375 (+)	100 bp
Tssr28979	Chr3:40904380-40904391 (+)	123 bp
Tssr28980	Chr3:40904398-40904403 (+)	138 bp
Tssr28981	Chr3:40904837-40904853 (+)	582 bp
Tssr28982	Chr3:40905073-40905092 (+)	820 bp
Tssr28983	Chr3:40905214-40905273 (+)	981 bp
Tssr28984	Chr3:40909471-40909479 (+)	5,212 bp
Tssr28985	Chr3:40913977-40913981 (+)	9,716 bp
Tssr28987	Chr3:40978804-40978819 (+)	74,549 bp