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Txndc8 Gene Detail
Summary
  • Symbol
    Txndc8
  • Name
    thioredoxin domain containing 8
  • Synonyms
    4930429J24Rik, Sptrx-3, Sptrx3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914652
    NCBI Gene: 67402
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:57984029-58009126 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 31.87 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    722 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914652
 protein coding gene Chr4:57984027-58009126 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028322
 protein coding gene Chr4:56800353-56826467 (-)
A/J MGP_AJ_G0028283
 protein coding gene Chr4:54642633-54672465 (-)
AKR/J MGP_AKRJ_G0028232
 protein coding gene Chr4:56159850-56196982 (-)
BALB/cJ MGP_BALBcJ_G0028302
 protein coding gene Chr4:54804264-54829894 (-)
C3H/HeJ MGP_C3HHeJ_G0028023
 protein coding gene Chr4:56652578-56679174 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028743
 protein coding gene Chr4:58827651-58856474 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026049
 protein coding gene Chr4:51415361-51439845 (-)
CAST/EiJ MGP_CASTEiJ_G0027461
 protein coding gene Chr4:56395869-56421389 (-)
CBA/J MGP_CBAJ_G0027988
 protein coding gene Chr4:60822525-60848411 (-)
DBA/2J MGP_DBA2J_G0028138
 protein coding gene Chr4:54543068-54568654 (-)
FVB/NJ MGP_FVBNJ_G0028105
 protein coding gene Chr4:53764287-53793580 (-)
LP/J MGP_LPJ_G0028237
 protein coding gene Chr4:56910183-56936231 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028129
 protein coding gene Chr4:63952799-63980175 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028779
 protein coding gene Chr4:56354973-56384576 (-)
PWK/PhJ MGP_PWKPhJ_G0027186
 protein coding gene Chr4:54545843-54571114 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027014
 protein coding gene Chr4:55632131-55658207 (-)
WSB/EiJ MGP_WSBEiJ_G0027539
 protein coding gene Chr4:56304150-56329676 (-)



Homology
more
  • Human Ortholog
    TXNDC8, thioredoxin domain containing 8
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TXNDC8, thioredoxin domain containing 8
  • Synonyms
    bA427L11.2, SPTRX-3, SPTRX3, TRX6
  • Links
    NCBI Gene ID: 255220
    neXtProt AC: NX_Q6A555
    UniProt: Q6A555

  • Chr Location
    9q31.3
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67402 NCBI Gene Model | MGI Sequence Detail 25098 C57BL/6J ±  kb
transcript NM_026132 RefSeq | MGI Sequence Detail 620 C57BL/6  
polypeptide Q69AB2 UniProt | EBI | MGI Sequence Detail 127 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
References
more
  • Summaries
    All 24
    Gene Ontology 6
    Phenotypes 1
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:92272 Jimenez A, et al., Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis. J Biol Chem. 2004 Aug 13;279(33):34971-82
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory