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Wdr13 Gene Detail
Summary
  • Symbol
    Wdr13
  • Name
    WD repeat domain 13
  • Synonyms
    1700060B08Rik, 5730411P10Rik, DXHXS7467e, mMg21
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914661
    NCBI Gene: 73447
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7989540-7999131 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.67 cM, cytoband A1.1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914661
 protein coding gene ChrX:7989540-7999134 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035540
 protein coding gene ChrX:2769522-2779109 (-)
A/J MGP_AJ_G0035517
 protein coding gene ChrX:2745421-2755022 (-)
AKR/J MGP_AKRJ_G0035450
 protein coding gene ChrX:2855336-2864927 (-)
BALB/cJ MGP_BALBcJ_G0035514
 protein coding gene ChrX:2742305-2751968 (-)
C3H/HeJ MGP_C3HHeJ_G0035222
 protein coding gene ChrX:2825812-2835607 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036038
 protein coding gene ChrX:2865195-2874785 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032913
 protein coding gene ChrX:2270519-2280062 (-)
CAST/EiJ MGP_CASTEiJ_G0034523
 protein coding gene ChrX:2713877-2723421 (-)
CBA/J MGP_CBAJ_G0035192
 protein coding gene ChrX:3014467-3024059 (-)
DBA/2J MGP_DBA2J_G0035349
 protein coding gene ChrX:2731118-2740707 (-)
FVB/NJ MGP_FVBNJ_G0035296
 protein coding gene ChrX:2695961-2706168 (-)
LP/J MGP_LPJ_G0035426
 protein coding gene ChrX:2791801-2801388 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035336
 protein coding gene ChrX:2964819-2974465 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036056
 protein coding gene ChrX:2750599-2760193 (-)
PWK/PhJ MGP_PWKPhJ_G0034223
 protein coding gene ChrX:2671910-2681762 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034062
 protein coding gene ChrX:2727411-2736904 (-)
WSB/EiJ MGP_WSBEiJ_G0034646
 protein coding gene ChrX:2754881-2764470 (-)



Homology
more
  • Human Ortholog
    WDR13, WD repeat domain 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR13, WD repeat domain 13
  • Synonyms
    MG21
  • Links
    NCBI Gene ID: 64743
    neXtProt AC: NX_Q9H1Z4
    UniProt: Q9H1Z4

  • Chr Location
    Xp11.23; chrX:48590042-48608869 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased pancreas beta cell proliferation, hyperinsulinemia and mild obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    31
  • cDNA Data
    89
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031166 Ensembl Gene Model | MGI Sequence Detail 9592 C57BL/6J ±  kb
    transcript ENSMUST00000033506 Ensembl | MGI Sequence Detail 4183 Not Applicable  
    polypeptide ENSMUSP00000033506 Ensembl | MGI Sequence Detail 485 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000029855 WD repeat-containing protein 13
      (term hierarchy)
    • InterPro Domains
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
      IPR051350 WD repeat-containing signal transduction regulator
    • GlyGen
      Q91V09 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 92
      Genomic 2
      cDNA 89
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1099465, MGI:1920697, MGI:2148087
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:55860 Derry JM, et al., Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com. Nat Genet. 1999 Jul;22(3):286-90
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory