Mfn1 MGI Mouse Gene Detail - MGI:1914664

Symbol

Mfn1
Name

mitofusin 1
Synonyms

2310002F04Rik, 6330416C07Rik, D3Ertd265e, HR2

Feature Type

protein coding gene
IDs

MGI:1914664
NCBI Gene: 67414
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:32583614-32633388 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 15.75 cM, cytoband B
Mapping Data

4 experiments

SNPs within 2kb

1361 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914664	protein coding gene	Chr3:32583594-32633388 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027139	protein coding gene	Chr3:30145779-30194505 (+)
A/J	MGP_AJ_G0027099	protein coding gene	Chr3:29714924-29766796 (+)
AKR/J	MGP_AKRJ_G0027068	protein coding gene	Chr3:30174160-30224103 (+)
BALB/cJ	MGP_BALBcJ_G0027111	protein coding gene	Chr3:29363611-29414343 (+)
C3H/HeJ	MGP_C3HHeJ_G0026854	protein coding gene	Chr3:30199637-30248450 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027557	protein coding gene	Chr3:31638080-31693677 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024918	protein coding gene	Chr3:27543768-27593761 (+)
CAST/EiJ	MGP_CASTEiJ_G0026307	protein coding gene	Chr3:30063323-30113882 (+)
CBA/J	MGP_CBAJ_G0026831	protein coding gene	Chr3:32488540-32542232 (+)
DBA/2J	MGP_DBA2J_G0026965	protein coding gene	Chr3:29183698-29233662 (+)
FVB/NJ	MGP_FVBNJ_G0026933	protein coding gene	Chr3:28643792-28693065 (+)
LP/J	MGP_LPJ_G0027077	protein coding gene	Chr3:30906766-30956548 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026953	protein coding gene	Chr3:34995376-35049699 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027616	protein coding gene	Chr3:29967252-30018624 (+)
PWK/PhJ	MGP_PWKPhJ_G0026040	protein coding gene	Chr3:28726497-28776464 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025852	protein coding gene	Chr3:29372603-29430374 (+)
WSB/EiJ	MGP_WSBEiJ_G0026381	protein coding gene	Chr3:29977819-30038278 (+)

Human Ortholog

MFN1, mitofusin 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MFN1, mitofusin 1
Synonyms

hfzo1, hfzo2
Links

HGNC:18262

NCBI Gene ID: 55669

neXtProt AC: NX_Q8IWA4

UniProt: Q8IWA4
Chr Location

3q26.33; chr3:179347709-179394936 (+) GRCh38

MGI Vertebrate Homology

Mfn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MFN1
Gene Tree

Mfn1

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References

1 with disease annotations

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Phenotype Summary

21 phenotypes from 4 alleles in 7 genetic backgrounds
26 phenotypes from multigenic genotypes
67 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

5
Gene trapped

7
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Mfn1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene die in mid gestation. Structural and functional abnormalities of mitochondria are reported.

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All GO Annotations

41
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

9
cDNA Data

14
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mfn1

ZFIN mfn1b

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All Sequences

70
RefSeq

3
UniProt

5
CCDS

CCDS17296.1

Ensembl

ENSMUSG00000027668 (Evidence)
NCBI Gene

67414

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027668	Ensembl Gene Model \| MGI Sequence Detail	49775	C57BL/6J	± kb
transcript	ENSMUST00000091257	Ensembl \| MGI Sequence Detail	4562	Not Applicable
polypeptide	ENSMUSP00000088801	Ensembl \| MGI Sequence Detail	741	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010369 mitofusin-1

(term hierarchy)
PDB

1T3J
EC

3.6.5.-
InterPro Domains

IPR045063 Dynamin, N-terminal

IPR030381 Dynamin-type guanine nucleotide-binding (G) domain

IPR006884 Fzo/mitofusin HR2 domain

IPR027094 Mitofusin family

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 19

Genomic 2

cDNA 14

Primer pair 3

Microarray probesets 9

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MGI:1098715, MGI:1916768

Summaries

All 143

Developmental Gene Expression 16

Diseases 1

Gene Ontology 13

Phenotypes 67
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:355753 Thomas D, et al., Role of Mitofusin 1 in mediating reactive oxygen species in alveolar macrophages during Streptococcuspneumoniae. Redox Biol. 2024 Oct;76:103329

TSS for Mfn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28756	Chr3:32583601-32583676 (+)	25 bp
Tssr28757	Chr3:32583681-32583692 (+)	73 bp
Tssr28758	Chr3:32583706-32583709 (+)	94 bp
Tssr28759	Chr3:32583728-32583777 (+)	139 bp
Tssr28760	Chr3:32583787-32583792 (+)	176 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24