Ears2 MGI Mouse Gene Detail - MGI:1914667 - glutamyl-tRNA synthetase 2, mitochondrial

Symbol

Ears2
Name

glutamyl-tRNA synthetase 2, mitochondrial
Synonyms

3230401I01Rik, mKIAA1970

Feature Type

protein coding gene
IDs

MGI:1914667
NCBI Gene: 67417
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:121636436-121666486 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 65.30 cM
Mapping Data

2 experiments

SNPs within 2kb

715 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914667	protein coding gene	Chr7:121633385-121666486 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032948	protein coding gene	Chr7:126098235-126131213 (-)
A/J	MGP_AJ_G0032931	protein coding gene	Chr7:122832927-122864903 (-)
AKR/J	MGP_AKRJ_G0032863	protein coding gene	Chr7:125954528-125986215 (-)
BALB/cJ	MGP_BALBcJ_G0032936	protein coding gene	Chr7:122522861-122554890 (-)
C3H/HeJ	MGP_C3HHeJ_G0032646	protein coding gene	Chr7:125883123-125913862 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033442	protein coding gene	Chr7:131081021-131111558 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030414	protein coding gene	Chr7:124157875-124187817 (-)
CAST/EiJ	MGP_CASTEiJ_G0031974	protein coding gene	Chr7:117657627-117690657 (-)
CBA/J	MGP_CBAJ_G0032619	protein coding gene	Chr7:135465510-135511635 (-)
DBA/2J	MGP_DBA2J_G0032771	protein coding gene	Chr7:120838213-120869209 (-)
FVB/NJ	MGP_FVBNJ_G0032724	protein coding gene	Chr7:120689119-120718854 (-)
LP/J	MGP_LPJ_G0032865	protein coding gene	Chr7:127548415-127577902 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032756	protein coding gene	Chr7:136857079-136888455 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033462	protein coding gene	Chr7:124960707-124993344 (-)
PWK/PhJ	MGP_PWKPhJ_G0031682	protein coding gene	Chr7:113766329-113797483 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031528	protein coding gene	Chr7:111733488-111766516 (-)
WSB/EiJ	MGP_WSBEiJ_G0032087	protein coding gene	Chr7:125868744-125900760 (-)

Human Ortholog

EARS2, glutamyl-tRNA synthetase 2, mitochondrial

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EARS2, glutamyl-tRNA synthetase 2, mitochondrial
Synonyms

COXPD12, gluRS, MSE1, mtGlnRS, mtGluRS
Links

HGNC:29419

NCBI Gene ID: 124454

neXtProt AC: NX_Q5JPH6

UniProt: Q5JPH6
Chr Location

16p12.2; chr16:23520754-23557731 (-) GRCh38

MGI Vertebrate Homology

Ears2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EARS2
Gene Tree

Ears2

Diseases

1 with human EARS2 associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 12 IDs combined oxidative phosphorylation deficiency 12 DOID:0111493 OMIM:614924 ORDO:314051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotype references

All Mutations and Alleles

19
Endonuclease-mediated

1
Gene trapped

15
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available

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All GO Annotations

18
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

9

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ears2

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All Sequences

48
RefSeq

5
UniProt

3
CCDS

CCDS21807.1

Ensembl

ENSMUSG00000030871 (Evidence)
NCBI Gene

67417

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030871	Ensembl Gene Model \| MGI Sequence Detail	30051	C57BL/6J	± kb
transcript	ENSMUST00000033159	Ensembl \| MGI Sequence Detail	2046	Not Applicable
polypeptide	ENSMUSP00000033159	Ensembl \| MGI Sequence Detail	523	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030548 nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

(term hierarchy)
EC

6.1.1.17, 6.1.1.24
InterPro Domains

IPR045462 Aminoacyl-tRNA synthetase, class I, anticodon-binding

IPR020751 Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2

IPR008925 Aminoacyl-tRNA synthetase, class I, anticodon-binding superfamily

IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site

IPR004527 Glutamate-tRNA ligase, bacterial/mitochondrial

IPR000924 Glutamyl/glutaminyl-tRNA synthetase

IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain

IPR049940 Glutamyl-Q tRNA(Asp) synthetase/Glutamate--tRNA ligase

IPR033910 Glutamyl-tRNA synthetase

IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 6

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MGI:2142095

Summaries

All 40

Gene Ontology 9

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ears2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr74570	Chr7:121666262-121666303 (-)	203 bp
Tssr74569	Chr7:121646137-121646156 (-)	20,339 bp
Tssr74568	Chr7:121646124-121646134 (-)	20,357 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24