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Mtfr1 Gene Detail
Summary
  • Symbol
    Mtfr1
  • Name
    mitochondrial fission regulator 1
  • Synonyms
    1300002C08Rik, 1700080D04Rik, 2810026O10Rik, 4930579E05Rik, Fam54a2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914722
    NCBI Gene: 67472
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:19241491-19274981 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 5.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1095 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914722
 protein coding gene Chr3:19241481-19274981 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027091
 protein coding gene Chr3:16382761-16417380 (+)
A/J MGP_AJ_G0027051
 protein coding gene Chr3:16316983-16351163 (+)
AKR/J MGP_AKRJ_G0027020
 protein coding gene Chr3:16461368-16494731 (+)
BALB/cJ MGP_BALBcJ_G0027063
 protein coding gene Chr3:16078130-16111754 (+)
C3H/HeJ MGP_C3HHeJ_G0026804
 protein coding gene Chr3:16497211-16530280 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027508
 protein coding gene Chr3:17455056-17488400 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024869
 protein coding gene Chr3:14401452-14437956 (+)
CAST/EiJ MGP_CASTEiJ_G0026259
 protein coding gene Chr3:16388696-16422906 (+)
CBA/J MGP_CBAJ_G0026782
 protein coding gene Chr3:17812284-17847887 (+)
DBA/2J MGP_DBA2J_G0026916
 protein coding gene Chr3:15922639-15956777 (+)
FVB/NJ MGP_FVBNJ_G0026884
 protein coding gene Chr3:15582641-15616084 (+)
LP/J MGP_LPJ_G0027028
 protein coding gene Chr3:17017551-17050847 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026905
 protein coding gene Chr3:19872907-19914435 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027567
 protein coding gene Chr3:16217678-16250825 (+)
PWK/PhJ MGP_PWKPhJ_G0025992
 protein coding gene Chr3:15634469-15669654 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025800
 protein coding gene Chr3:16048627-16081492 (+)
WSB/EiJ MGP_WSBEiJ_G0026333
 protein coding gene Chr3:16270521-16304971 (+)



Homology
more
  • Human Ortholog
    MTFR1, mitochondrial fission regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTFR1, mitochondrial fission regulator 1
  • Synonyms
    CHPPR, FAM54A2
  • Links
    NCBI Gene ID: 9650
    neXtProt AC: NX_Q15390
    UniProt: Q15390

  • Chr Location
    8q13.1; chr8:65643889-65778598 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    44
  • Endonuclease-mediated
    2
  • Gene trapped
    39
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Mtfr1
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    39 strains or lines available
Mice homozygous for a gene trapped allele exhibit increased oxidative DNA damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    5
  • cDNA Data
    17
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027601 Ensembl Gene Model | MGI Sequence Detail 33491 C57BL/6J ±  kb
transcript ENSMUST00000117529 Ensembl | MGI Sequence Detail 1896 Not Applicable  
polypeptide ENSMUSP00000112824 Ensembl | MGI Sequence Detail 328 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1919894, MGI:1923101, MGI:1924244
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory