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Ero1b Gene Detail
Summary
  • Symbol
    Ero1b
  • Name
    endoplasmic reticulum oxidoreductase 1 beta
  • Synonyms
    1300013B24Rik, 1700065B09Rik, Ero1lb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914725
    NCBI Gene: 67475
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:12580701-12624422 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 5.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1771 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914725
 protein coding gene Chr13:12580701-12626285 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0020189
 protein coding gene Chr13:9153496-9211680 (+)
AKR/J MGP_AKRJ_G0020164
 protein coding gene Chr13:9358365-9402157 (+)
BALB/cJ MGP_BALBcJ_G0020172
 protein coding gene Chr13:9138853-9193571 (+)
C3H/HeJ MGP_C3HHeJ_G0019976
 protein coding gene Chr13:9493800-9555849 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020619
 protein coding gene Chr13:9762083-9870203 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018226
 protein coding gene Chr13:8984272-9027472 (+)
CAST/EiJ MGP_CASTEiJ_G0019514
 protein coding gene Chr13:9202097-9295205 (+)
CBA/J MGP_CBAJ_G0019943
 protein coding gene Chr13:10019019-10114032 (+)
DBA/2J MGP_DBA2J_G0020060
 protein coding gene Chr13:8977815-9033285 (+)
FVB/NJ MGP_FVBNJ_G0020045
 protein coding gene Chr13:8791928-8837209 (+)
LP/J MGP_LPJ_G0020134
 protein coding gene Chr13:9431312-9496432 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020081
 protein coding gene Chr13:10313858-10391188 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020647
 protein coding gene Chr13:9254186-9293695 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0019084
 protein coding gene Chr13:9249107-9296022 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ERO1B, endoplasmic reticulum oxidoreductase 1 beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERO1B, endoplasmic reticulum oxidoreductase 1 beta
  • Synonyms
    Ero1beta, ERO1LB
  • Links
    NCBI Gene ID: 56605
    neXtProt AC: NX_Q86YB8
    UniProt: Q86YB8

  • Chr Location
    1q42.3; chr1:236214681-236282019 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit increased circulating glucose levels, decreased pancreas insulin levels, and disorganized islets.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    3
  • cDNA Data
    68
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67475 NCBI Gene Model | MGI Sequence Detail 43722 C57BL/6J ±  kb
    transcript NM_026184 RefSeq | MGI Sequence Detail 4214 C57BL/6  
    polypeptide Q8R2E9 UniProt | EBI | MGI Sequence Detail 467 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 68
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920689, MGI:2145237, MGI:6390572
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:335234 Parveen N, et al., DNA methylation Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic beta-cell Heterogeneity. Diabetes. 2023 Jan 6;72(5):575-89
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory