Abhd15 MGI Mouse Gene Detail - MGI:1914727 - abhydrolase domain containing 15

Symbol

Abhd15
Name

abhydrolase domain containing 15
Synonyms

1300007F04Rik

Feature Type

protein coding gene
IDs

MGI:1914727
NCBI Gene: 67477
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:77405943-77411454 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.63 cM, cytoband B5
Mapping Data

2 experiments

SNPs within 2kb

217 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914727	protein coding gene	Chr11:77405943-77429433 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018750	protein coding gene	Chr11:78424792-78450518 (+)
A/J	MGP_AJ_G0018716	protein coding gene	Chr11:75461267-75484754 (+)
AKR/J	MGP_AKRJ_G0018686	protein coding gene	Chr11:77751149-77774625 (+)
BALB/cJ	MGP_BALBcJ_G0018690	protein coding gene	Chr11:75846811-75870304 (+)
C3H/HeJ	MGP_C3HHeJ_G0018503	protein coding gene	Chr11:77774322-77798341 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019141	protein coding gene	Chr11:80885073-80909538 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016776	protein coding gene	Chr11:72442779-72466227 (+)
CAST/EiJ	MGP_CASTEiJ_G0018057	protein coding gene	Chr11:78171931-78197830 (+)
CBA/J	MGP_CBAJ_G0018473	protein coding gene	Chr11:84400868-84426644 (+)
DBA/2J	MGP_DBA2J_G0018582	protein coding gene	Chr11:75047839-75071637 (+)
FVB/NJ	MGP_FVBNJ_G0018572	protein coding gene	Chr11:74618235-74641716 (+)
LP/J	MGP_LPJ_G0018653	protein coding gene	Chr11:78984334-79007809 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018598	protein coding gene	Chr11:84855310-84881925 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019181	protein coding gene	Chr11:77960770-77985297 (+)
PWK/PhJ	MGP_PWKPhJ_G0017828	protein coding gene	Chr11:75805084-75829570 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017619	protein coding gene	Chr11:77577194-77600687 (+)
WSB/EiJ	MGP_WSBEiJ_G0018110	protein coding gene	Chr11:77783366-77810418 (+)

Human Ortholog

ABHD15, abhydrolase domain containing 15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ABHD15, abhydrolase domain containing 15
Links

HGNC:26971

NCBI Gene ID: 116236

neXtProt AC: NX_Q6UXT9

UniProt: Q6UXT9
Chr Location

17q11.2; chr17:29560547-29567037 (-) GRCh38

MGI Vertebrate Homology

Abhd15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ABHD15
Protein SuperFamily

Ab_hydro_YheT
Gene Tree

Abhd15

less

Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Targeted

7
Genomic Mutations

2 involving Abhd15
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

8
cDNA Data

10
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase abhd15

less

All Sequences

44
RefSeq

2
UniProt

5
CCDS

CCDS36234.1

Ensembl

ENSMUSG00000000686 (Evidence)
NCBI Gene

67477

			Length	Strain/Species	Flank
genomic	67477	NCBI Gene Model \| MGI Sequence Detail	5512	C57BL/6J	± kb
transcript	NM_026185	RefSeq \| MGI Sequence Detail	3249	C57BL/6
polypeptide	Q5F2F2	UniProt \| EBI \| MGI Sequence Detail	459	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000032041 protein ABHD15

(term hierarchy)
InterPro Domains

IPR012020 AB hydrolase 4 family

IPR050960 AB hydrolase superfamily, subfamily 4

IPR029058 Alpha/Beta hydrolase fold

less

All nucleic 10

cDNA 10

Microarray probesets 4

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Abhd15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103159	Chr11:77404337-77404363 (+)	-1,593 bp
Tssr103160	Chr11:77405930-77405954 (+)	-1 bp
Tssr103161	Chr11:77409392-77409402 (+)	3,454 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24