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Ufl1 Gene Detail
Summary
  • Symbol
    Ufl1
  • Name
    UFM1 specific ligase 1
  • Synonyms
    1810074P20Rik, Maxer, mKIAA0776, Rcad
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914740
    NCBI Gene: 67490
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:25248600-25281821 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 10.59 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1005 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914740
 protein coding gene Chr4:25247149-25281821 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028103
 protein coding gene Chr4:22351925-22386463 (-)
A/J MGP_AJ_G0028061
 protein coding gene Chr4:21711506-21745360 (-)
AKR/J MGP_AKRJ_G0028026
 protein coding gene Chr4:22190592-22225814 (-)
BALB/cJ MGP_BALBcJ_G0028072
 protein coding gene Chr4:21766525-21800423 (-)
C3H/HeJ MGP_C3HHeJ_G0027802
 protein coding gene Chr4:22377351-22410193 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028515
 protein coding gene Chr4:23330527-23364814 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025857
 protein coding gene Chr4:20163941-20197363 (-)
CAST/EiJ MGP_CASTEiJ_G0027257
 protein coding gene Chr4:22090193-22130220 (-)
CBA/J MGP_CBAJ_G0027775
 protein coding gene Chr4:23939784-23978193 (-)
DBA/2J MGP_DBA2J_G0027918
 protein coding gene Chr4:21607545-21640694 (-)
FVB/NJ MGP_FVBNJ_G0027884
 protein coding gene Chr4:21246322-21280054 (-)
LP/J MGP_LPJ_G0028027
 protein coding gene Chr4:22461659-22496863 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027917
 protein coding gene Chr4:25465222-25500610 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028574
 protein coding gene Chr4:22163784-22197765 (-)
PWK/PhJ MGP_PWKPhJ_G0026977
 protein coding gene Chr4:21291959-21325360 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026805
 protein coding gene Chr4:21929796-21963684 (-)
WSB/EiJ MGP_WSBEiJ_G0027334
 protein coding gene Chr4:22107932-22143483 (-)



Homology
more
  • Human Ortholog
    UFL1, UFM1 specific ligase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UFL1, UFM1 specific ligase 1
  • Synonyms
    KIAA0776, Maxer, NLBP, RCAD
  • Links
    NCBI Gene ID: 23376
    neXtProt AC: NX_O94874
    UniProt: O94874

  • Chr Location
    6q16.1; chr6:96521595-96555276 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality during organogensis, anemia and decreased erythroid progenitor cell number.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    6
  • cDNA Data
    16
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040359 Ensembl Gene Model | MGI Sequence Detail 33222 C57BL/6J ±  kb
    transcript ENSMUST00000102994 Ensembl | MGI Sequence Detail 4316 Not Applicable  
    polypeptide ENSMUSP00000100059 Ensembl | MGI Sequence Detail 793 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2140276
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Gene Ontology 14
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347152 He C, et al., UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity. Mol Cell. 2024 Mar 21;84(6):1120-1138.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory