Kcnv1 MGI Mouse Gene Detail - MGI:1914748 - potassium channel, subfamily V, member 1

Symbol

Kcnv1
Name

potassium channel, subfamily V, member 1
Synonyms

2700023A03Rik

Feature Type

protein coding gene
IDs

MGI:1914748
NCBI Gene: 67498
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:44969680-44978316 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 17.25 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

332 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914748	protein coding gene	Chr15:44959482-44979375 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021834	protein coding gene	Chr15:43728967-43737604 (-)
A/J	MGP_AJ_G0021794	protein coding gene	Chr15:42071830-42080473 (-)
AKR/J	MGP_AKRJ_G0021775	protein coding gene	Chr15:43304926-43313549 (-)
BALB/cJ	MGP_BALBcJ_G0021801	protein coding gene	Chr15:42145865-42154972 (-)
C3H/HeJ	MGP_C3HHeJ_G0021575	protein coding gene	Chr15:43226071-43234694 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022240	protein coding gene	Chr15:45422423-45425667 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019777	protein coding gene	Chr15:39569157-39577922 (-)
CAST/EiJ	MGP_CASTEiJ_G0021092	protein coding gene	Chr15:43727595-43737596 (-)
CBA/J	MGP_CBAJ_G0021544	protein coding gene	Chr15:46984631-46993259 (-)
DBA/2J	MGP_DBA2J_G0021668	protein coding gene	Chr15:41877940-41886576 (-)
FVB/NJ	MGP_FVBNJ_G0021646	protein coding gene	Chr15:41166933-41175568 (-)
LP/J	MGP_LPJ_G0021738	protein coding gene	Chr15:43513003-43521695 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021670	protein coding gene	Chr15:50431454-50439583 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022263	protein coding gene	Chr15:43507586-43516208 (-)
PWK/PhJ	MGP_PWKPhJ_G0020837	protein coding gene	Chr15:41918811-41927468 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020674	protein coding gene	Chr15:43167644-43176243 (-)
WSB/EiJ	MGP_WSBEiJ_G0021147	protein coding gene	Chr15:43401017-43410577 (-)

Human Ortholog

KCNV1, potassium voltage-gated channel modifier subfamily V member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNV1, potassium voltage-gated channel modifier subfamily V member 1
Synonyms

HNKA, KCNB3, KV2.3, KV8.1
Links

HGNC:18861

NCBI Gene ID: 27012

neXtProt AC: NX_Q6PIU1

UniProt: Q6PIU1
Chr Location

8q23.2; chr8:109963636-109975771 (-) GRCh38

MGI Vertebrate Homology

Kcnv1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KCNV1
Gene Tree

Kcnv1

less

Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

1
Targeted

2
Genomic Mutations

2 involving Kcnv1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available

At weaning, homozygous mutant mice exhibit tetany, tremors and ataxia.

less

All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnv1

less

All Sequences

42
RefSeq

4
UniProt

1
CCDS

CCDS27459.1

Ensembl

ENSMUSG00000022342 (Evidence)
NCBI Gene

67498

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022342	Ensembl Gene Model \| MGI Sequence Detail	8637	C57BL/6J	± kb
transcript	ENSMUST00000022967	Ensembl \| MGI Sequence Detail	4389	Not Applicable
polypeptide	ENSMUSP00000022967	Ensembl \| MGI Sequence Detail	503	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000000725 voltage-gated potassium channel KCNV1

(term hierarchy)
InterPro Domains

IPR000210 BTB/POZ domain

IPR005821 Ion transport domain

IPR003131 Potassium channel tetramerisation-type BTB domain

IPR003968 Potassium channel, voltage dependent, Kv

IPR003970 Potassium channel, voltage dependent, Kv8.1

IPR011333 SKP1/BTB/POZ domain superfamily

IPR027359 Voltage-dependent channel domain superfamily

less

All nucleic 12

cDNA 12

Microarray probesets 5

less

MGI:3584402

Summaries

All 38

Gene Ontology 6

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kcnv1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134215	Chr15:44978322-44978334 (-)	-12 bp
Tssr134214	Chr15:44978292-44978304 (-)	18 bp
Tssr134213	Chr15:44978259-44978268 (-)	52 bp
Tssr134212	Chr15:44978056-44978072 (-)	252 bp
Tssr134211	Chr15:44977837-44977857 (-)	469 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24