Dennd4c MGI Mouse Gene Detail - MGI:1914769

Symbol

Dennd4c
Name

DENN domain containing 4C
Synonyms

1700065A05Rik

Feature Type

protein coding gene
IDs

MGI:1914769
NCBI Gene: 329877
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr4:86666792-86768840 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 40.69 cM
Mapping Data

2 experiments

SNPs within 2kb

2457 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914769	protein coding gene	Chr4:86666761-86768841 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028414	protein coding gene	Chr4:86526995-86629252 (+)
A/J	MGP_AJ_G0028375	protein coding gene	Chr4:83558333-83659185 (+)
AKR/J	MGP_AKRJ_G0028324	protein coding gene	Chr4:85621192-85725755 (+)
BALB/cJ	MGP_BALBcJ_G0028395	protein coding gene	Chr4:83738781-83836659 (+)
C3H/HeJ	MGP_C3HHeJ_G0028110	protein coding gene	Chr4:86297529-86399277 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028834	protein coding gene	Chr4:89832598-89967080 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026134	protein coding gene	Chr4:79598706-79693949 (+)
CAST/EiJ	MGP_CASTEiJ_G0027551	protein coding gene	Chr4:84159090-84261469 (+)
CBA/J	MGP_CBAJ_G0028079	protein coding gene	Chr4:92602802-92707852 (+)
DBA/2J	MGP_DBA2J_G0028228	protein coding gene	Chr4:83279659-83395049 (+)
FVB/NJ	MGP_FVBNJ_G0028194	protein coding gene	Chr4:82265852-82372004 (+)
LP/J	MGP_LPJ_G0028328	protein coding gene	Chr4:86865689-86974438 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028223	protein coding gene	Chr4:97660216-97767781 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028871	protein coding gene	Chr4:85697062-85812829 (+)
PWK/PhJ	MGP_PWKPhJ_G0027274	protein coding gene	Chr4:81603971-81710814 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027099	protein coding gene	Chr4:83245909-83347472 (+)
WSB/EiJ	MGP_WSBEiJ_G0027627	protein coding gene	Chr4:85906417-86016875 (+)

Human Ortholog

DENND4C, DENN domain containing 4C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DENND4C, DENN domain containing 4C
Synonyms

bA513M16.3, C9orf55, C9orf55B, RAB10GEF
Links

HGNC:26079

NCBI Gene ID: 55667

neXtProt AC: NX_Q5VZ89

UniProt: Q5VZ89
Chr Location

9p22.1; chr9:19230435-19374281 (+) GRCh38

MGI Vertebrate Homology

Dennd4c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DENND4C
Gene Tree

Dennd4c

less

Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

6
Radiation induced

1
Targeted

4
Genomic Mutations

5 involving Dennd4c
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

82 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal visceral yolk sac morphology, defects in placentation with abnormal trophoblast layer formation, and complete lethality throughout fetal growth and development.

less

All GO Annotations

16
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

13

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dennd4c

less

All Sequences

58
RefSeq

14
UniProt

3
CCDS

CCDS51218.2

Ensembl

ENSMUSG00000038024 (Evidence)
NCBI Gene

329877

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038024	Ensembl Gene Model \| MGI Sequence Detail	102049	C57BL/6J	± kb
transcript	ENSMUST00000082026	Ensembl \| MGI Sequence Detail	7940	Not Applicable
polypeptide	ENSMUSP00000080685	Ensembl \| MGI Sequence Detail	1955	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000030676 DENN domain-containing protein 4C

(term hierarchy)
InterPro Domains

IPR001194 cDENN domain

IPR005112 dDENN domain

IPR051696 DENN Domain-Containing GEFs

IPR043153 DENN domain, C-terminal lobe

IPR023341 MABP domain

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR037516 Tripartite DENN domain

IPR005113 uDENN domain
GlyGen

A6H8H2 4 sites, 4 N-linked glycans (4 sites)

less

All nucleic 13

cDNA 13

Microarray probesets 3

less

MGI:2140156

Summaries

All 46

Gene Ontology 7

Phenotypes 17
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dennd4c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37742	Chr4:86666763-86666795 (+)	-13 bp
Tssr37743	Chr4:86666798-86666809 (+)	12 bp
Tssr37744	Chr4:86666820-86666835 (+)	36 bp
Tssr37745	Chr4:86666855-86666860 (+)	66 bp
Tssr37746	Chr4:86666872-86666882 (+)	85 bp
Tssr37747	Chr4:86667088-86667099 (+)	302 bp
Tssr1222	Chr4:86714802-86714805 (+)	48,012 bp
Tssr37748	Chr4:86742141-86742147 (+)	75,352 bp
Tssr37749	Chr4:86763016-86763027 (+)	96,230 bp
Tssr37750	Chr4:86763037-86763052 (+)	96,253 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24