About   Help   FAQ
Cog6 Gene Detail
Summary
  • Symbol
    Cog6
  • Name
    component of oligomeric golgi complex 6
  • Synonyms
    mKIAA1134
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914792
    NCBI Gene: 67542
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:52889544-52924644 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 24.10 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1002 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914792
 protein coding gene Chr3:52889296-52924658 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027203
 protein coding gene Chr3:51558018-51594311 (-)
A/J MGP_AJ_G0027163
 protein coding gene Chr3:50011757-50047116 (-)
AKR/J MGP_AKRJ_G0027132
 protein coding gene Chr3:51021653-51056581 (-)
BALB/cJ MGP_BALBcJ_G0027175
 protein coding gene Chr3:49881649-49916873 (-)
C3H/HeJ MGP_C3HHeJ_G0026918
 protein coding gene Chr3:51255065-51291309 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027621
 protein coding gene Chr3:53554452-53590683 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024981
 protein coding gene Chr3:46609495-46644238 (-)
CAST/EiJ MGP_CASTEiJ_G0026371
 protein coding gene Chr3:51335147-51374038 (-)
CBA/J MGP_CBAJ_G0026895
 protein coding gene Chr3:55263851-55301306 (-)
DBA/2J MGP_DBA2J_G0027029
 protein coding gene Chr3:49596795-49632660 (-)
FVB/NJ MGP_FVBNJ_G0026997
 protein coding gene Chr3:48581684-48616986 (-)
LP/J MGP_LPJ_G0027141
 protein coding gene Chr3:52292257-52331543 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027015
 protein coding gene Chr3:59400659-59436691 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027680
 protein coding gene Chr3:50933183-50969384 (-)
PWK/PhJ MGP_PWKPhJ_G0026103
 protein coding gene Chr3:49260573-49296475 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025916
 protein coding gene Chr3:50649173-50684378 (-)
WSB/EiJ MGP_WSBEiJ_G0026445
 protein coding gene Chr3:51045879-51083423 (-)



Homology
more
  • Human Ortholog
    COG6, component of oligomeric golgi complex 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COG6, component of oligomeric golgi complex 6
  • Synonyms
    CDG2L, COD2, SHNS
  • Links
    NCBI Gene ID: 57511
    neXtProt AC: NX_Q9Y2V7
    UniProt: Q9Y2V7

  • Chr Location
    13q14.11; chr13:39655627-39791666 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human COG6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    71 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    2
  • cDNA Data
    11
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67542 NCBI Gene Model | MGI Sequence Detail 35101 C57BL/6J ±  kb
    transcript NM_026225 RefSeq | MGI Sequence Detail 2920 C57BL/6  
    polypeptide Q8R3I3 UniProt | EBI | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005689 conserved oligomeric Golgi complex subunit 6
      (term hierarchy)
    • InterPro Domains
      IPR048368 Conserved oligomeric complex COG6, N-terminal
      IPR010490 Conserved oligomeric Golgi complex subunit 6
      IPR048369 Conserved Oligomeric Golgi complex subunit 6, C-terminal
    • GlyGen
      Q8R3I3 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139872
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory