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Alg13 Gene Detail
Summary
  • Symbol
    Alg13
  • Name
    asparagine-linked glycosylation 13
  • Synonyms
    2810046O15Rik, 4833435D08Rik, Glt28d1, MDS031
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914824
    NCBI Gene: 67574
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:143100962-143157446 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 65.42 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1038 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914824
 protein coding gene ChrX:143100800-143157446 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036158
 protein coding gene ChrX:141870633-141929428 (+)
A/J MGP_AJ_G0036135
 protein coding gene ChrX:141185280-141241174 (+)
AKR/J MGP_AKRJ_G0036061
 protein coding gene ChrX:145777407-145844158 (+)
BALB/cJ MGP_BALBcJ_G0036126
 protein coding gene ChrX:139429059-139489003 (+)
C3H/HeJ MGP_C3HHeJ_G0035834
 protein coding gene ChrX:141964189-142026098 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036649
 protein coding gene ChrX:145884874-145942872 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033473
 protein coding gene ChrX:132765135-132821160 (+)
CAST/EiJ MGP_CASTEiJ_G0035125
 protein coding gene ChrX:122617111-122683620 (+)
CBA/J MGP_CBAJ_G0035811
 protein coding gene ChrX:150381187-150440077 (+)
DBA/2J MGP_DBA2J_G0035969
 protein coding gene ChrX:140280778-140338964 (+)
FVB/NJ MGP_FVBNJ_G0035903
 protein coding gene ChrX:139491770-139549331 (+)
LP/J MGP_LPJ_G0036060
 protein coding gene ChrX:142814940-142872252 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035939
 protein coding gene ChrX:158165924-158232223 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036686
 protein coding gene ChrX:141164821-141230538 (+)
PWK/PhJ MGP_PWKPhJ_G0034819
 protein coding gene ChrX:119411564-119467760 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034644
 protein coding gene ChrX:123152073-123224631 (+)
WSB/EiJ MGP_WSBEiJ_G0035260
 protein coding gene ChrX:139521454-139580858 (+)



Homology
more
  • Human Ortholog
    ALG13, ALG13 UDP-N-acetylglucosaminyltransferase subunit
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALG13, ALG13 UDP-N-acetylglucosaminyltransferase subunit
  • Synonyms
    CDG1S, CXorf45, DEE36, EIEE36, GLT28D1, MDS031, TDRD13, YGL047W
  • Links
    NCBI Gene ID: 79868
    neXtProt AC: NX_Q9NP73
    UniProt: Q9NP73

  • Chr Location
    Xq23; chrX:111665811-111760649 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ALG13 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    44 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males hemizygous for a null allele exhibit environmentally induced seizures and increased susceptibility to pharmacologically induced seizures. Homozygous females for a different null allele show increased body fat and decrased lean body mass, decreased bone mineral density, decreased granulocyte numbers and increased leukocyte numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    98
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67574 NCBI Gene Model | MGI Sequence Detail 56485 C57BL/6J ±  kb
    transcript NR_037145 RefSeq | MGI Sequence Detail 4239 C57BL/6  
    polypeptide Q9D8C3 UniProt | EBI | MGI Sequence Detail 1166 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • EC
      2.4.1.141, 3.4.19.12
    • InterPro Domains
      IPR047387 Bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13, OTU domain
      IPR007235 Glycosyl transferase, family 28, C-terminal
      IPR003323 OTU domain
      IPR050704 OTU domain-containing ubiquitin thioesterase
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR002999 Tudor domain
      IPR039042 UDP-N-acetylglucosamine transferase subunit Alg13-like
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919938, MGI:3709593
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory