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Patl2 Gene Detail
Summary
  • Symbol
    Patl2
  • Name
    protein associated with topoisomerase II homolog 2 (yeast)
  • Synonyms
    4930424G05Rik, Pat1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914828
    NCBI Gene: 67578
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:121950589-122016670 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.53 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1549 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914828
 protein coding gene Chr2:121950589-122016670 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026405
 protein coding gene Chr2:125102023-125175213 (-)
A/J MGP_AJ_G0026367
 protein coding gene Chr2:119992322-120058663 (-)
AKR/J MGP_AKRJ_G0026344
 protein coding gene Chr2:123350795-123422619 (-)
BALB/cJ MGP_BALBcJ_G0026379
 protein coding gene Chr2:120217276-120293958 (-)
C3H/HeJ MGP_C3HHeJ_G0026124
 protein coding gene Chr2:123839886-123908122 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026826
 protein coding gene Chr2:129165298-129236910 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024205
 protein coding gene Chr2:114964291-115032726 (-)
CAST/EiJ MGP_CASTEiJ_G0025586
 protein coding gene Chr2:124167051-124243887 (-)
CBA/J MGP_CBAJ_G0026103
 protein coding gene Chr2:133720413-133793555 (-)
DBA/2J MGP_DBA2J_G0026240
 protein coding gene Chr2:119388559-119458163 (-)
FVB/NJ MGP_FVBNJ_G0026202
 protein coding gene Chr2:118179861-118247916 (-)
LP/J MGP_LPJ_G0026342
 protein coding gene Chr2:125351638-125428421 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026222
 protein coding gene Chr2:137925932-138003187 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026881
 protein coding gene Chr2:123465265-123539164 (-)
PWK/PhJ MGP_PWKPhJ_G0025322
 protein coding gene Chr2:118999530-119067764 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025122
 protein coding gene Chr2:122608373-122678957 (-)
WSB/EiJ MGP_WSBEiJ_G0025658
 protein coding gene Chr2:124325499-124396122 (-)



Homology
more
  • Human Ortholog
    PATL2, PAT1 homolog 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PATL2, PAT1 homolog 2
  • Synonyms
    hPat1a, OOMD4, OZEMA4, Pat1a
  • Links
    NCBI Gene ID: 197135
    neXtProt AC: NX_C9JE40
    UniProt: C9JE40

  • Chr Location
    15q21.1; chr15:44665732-44711390 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Patl2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defects in oocyte maturation, abnormal female meiosis I arrest, reduced female fertility, and impaired fertilization affecting preimplantation embryo development. Male fertility is normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67578 NCBI Gene Model | MGI Sequence Detail 66082 C57BL/6J ±  kb
    transcript NM_026251 RefSeq | MGI Sequence Detail 2434 C57BL/6  
    polypeptide A2ARM1 UniProt | EBI | MGI Sequence Detail 529 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 2
    References
    more
    • Summaries
      All 33
      Diseases 1
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory