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Cpeb4 Gene Detail
Summary
  • Symbol
    Cpeb4
  • Name
    cytoplasmic polyadenylation element binding protein 4
  • Synonyms
    4930447D24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914829
    NCBI Gene: 67579
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:31822211-31885634 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 18.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1222 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914829
 protein coding gene Chr11:31820911-31885635 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018123
 protein coding gene Chr11:30025729-30100080 (+)
A/J MGP_AJ_G0018096
 protein coding gene Chr11:28913570-28977075 (+)
AKR/J MGP_AKRJ_G0018060
 protein coding gene Chr11:29829742-29892666 (+)
BALB/cJ MGP_BALBcJ_G0018065
 protein coding gene Chr11:29105901-29169063 (+)
C3H/HeJ MGP_C3HHeJ_G0017878
 protein coding gene Chr11:29774469-29839751 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018517
 protein coding gene Chr11:31029351-31096353 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016172
 protein coding gene Chr11:27438429-27501500 (+)
CAST/EiJ MGP_CASTEiJ_G0017440
 protein coding gene Chr11:29792579-29860171 (+)
CBA/J MGP_CBAJ_G0017851
 protein coding gene Chr11:32485439-32562613 (+)
DBA/2J MGP_DBA2J_G0017961
 protein coding gene Chr11:28705766-28776716 (+)
FVB/NJ MGP_FVBNJ_G0017955
 protein coding gene Chr11:28524772-28587619 (+)
LP/J MGP_LPJ_G0018033
 protein coding gene Chr11:30276752-30341826 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017979
 protein coding gene Chr11:33531291-33599636 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018558
 protein coding gene Chr11:29943445-30006722 (+)
PWK/PhJ MGP_PWKPhJ_G0017222
 protein coding gene Chr11:28847707-28911488 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017016
 protein coding gene Chr11:29650712-29716403 (+)
WSB/EiJ MGP_WSBEiJ_G0017492
 protein coding gene Chr11:29575213-29640353 (+)



Homology
more
  • Human Ortholog
    CPEB4, cytoplasmic polyadenylation element binding protein 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPEB4, cytoplasmic polyadenylation element binding protein 4
  • Synonyms
    CPE-BP4, hCPEB-4
  • Links
    NCBI Gene ID: 80315
    neXtProt AC: NX_Q17RY0
    UniProt: Q17RY0

  • Chr Location
    5q35.2; chr5:173888349-173961980 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 4 alleles in 5 genetic backgrounds
    3 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show slightly longer dendritic spines but normal hippocampal synaptic plasticity and memory. Homozygotes for a different null allele show neo- and postnatal lethality, erythropoiesis, suckling and mobility defects, and reduced motor axon branching and NMJ formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    45
  • cDNA Data
    72
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020300 Ensembl Gene Model | MGI Sequence Detail 63424 C57BL/6J ±  kb
    transcript ENSMUST00000020543 Ensembl | MGI Sequence Detail 2312 Not Applicable  
    polypeptide ENSMUSP00000020543 Ensembl | MGI Sequence Detail 729 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000005808 cytoplasmic polyadenylation element-binding protein 4
      (term hierarchy)
    • InterPro Domains
      IPR038446 CEBP, ZZ domain superfamily
      IPR034819 Cytoplasmic polyadenylation element-binding protein
      IPR032296 Cytoplasmic polyadenylation element-binding protein, ZZ domain
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 73
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2144310
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 25
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory