Get4 MGI Mouse Gene Detail - MGI:1914854 - golgi to ER traffic protein 4

Symbol

Get4
Name

golgi to ER traffic protein 4
Synonyms

1110007L15Rik

Feature Type

protein coding gene
IDs

MGI:1914854
NCBI Gene: 67604
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:139238079-139255806 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 78.23 cM
Mapping Data

2 experiments

SNPs within 2kb

480 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914854	protein coding gene	Chr5:139237303-139255806 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030278	protein coding gene	Chr5:144209223-144226940 (+)
A/J	MGP_AJ_G0030247	protein coding gene	Chr5:138104459-138122775 (+)
AKR/J	MGP_AKRJ_G0030179	protein coding gene	Chr5:142408607-142428848 (+)
BALB/cJ	MGP_BALBcJ_G0030264	protein coding gene	Chr5:139352309-139370249 (+)
C3H/HeJ	MGP_C3HHeJ_G0029975	protein coding gene	Chr5:143182040-143198907 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030709	protein coding gene	Chr5:149529327-149549592 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027927	protein coding gene	Chr5:131965185-131983105 (+)
CAST/EiJ	MGP_CASTEiJ_G0029380	protein coding gene	Chr5:142591413-142609217 (+)
CBA/J	MGP_CBAJ_G0029945	protein coding gene	Chr5:155696537-155713416 (+)
DBA/2J	MGP_DBA2J_G0030095	protein coding gene	Chr5:137919049-137936771 (+)
FVB/NJ	MGP_FVBNJ_G0030050	protein coding gene	Chr5:137019462-137038408 (+)
LP/J	MGP_LPJ_G0030181	protein coding gene	Chr5:144830668-144848389 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030081	protein coding gene	Chr5:158382462-158400184 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030749	protein coding gene	Chr5:142217713-142235435 (+)
PWK/PhJ	MGP_PWKPhJ_G0029095	protein coding gene	Chr5:136913277-136930161 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028931	protein coding gene	Chr5:139902624-139919768 (+)
WSB/EiJ	MGP_WSBEiJ_G0029454	protein coding gene	Chr5:142982412-143000149 (+)

Human Ortholog

GET4, guided entry of tail-anchored proteins factor 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GET4, guided entry of tail-anchored proteins factor 4
Synonyms

C7orf20, CDG2Y, CEE, CGI-20, TRC35
Links

HGNC:21690

NCBI Gene ID: 51608

neXtProt AC: NX_Q7L5D6

UniProt: Q7L5D6
Chr Location

7p22.3; chr7:876554-896436 (+) GRCh38

MGI Vertebrate Homology

Get4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GET4
Gene Tree

Get4

Diseases

1 with human GET4 associations

				Human Disease	Mouse Models
				congenital disorder of glycosylation type II IDs congenital disorder of glycosylation type II DOID:0050571 MESH:C535747 OMIM:PS212066

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

44
Endonuclease-mediated

1
Gene trapped

43
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available

less

All GO Annotations

32
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

7
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase get4

ZFIN get4

less

All Sequences

59
RefSeq

11
UniProt

3
CCDS

CCDS19805.1, CCDS51682.1

Ensembl

ENSMUSG00000025858 (Evidence)
NCBI Gene

67604

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025858	Ensembl Gene Model \| MGI Sequence Detail	17728	C57BL/6J	± kb
transcript	ENSMUST00000026976	Ensembl \| MGI Sequence Detail	2107	Not Applicable
polypeptide	ENSMUSP00000026976	Ensembl \| MGI Sequence Detail	327	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000032043 Golgi to ER traffic protein 4 homolog

(term hierarchy)
InterPro Domains

IPR007317 Golgi to ER traffic protein 4

IPR011990 Tetratricopeptide-like helical domain superfamily

less

All nucleic 9

cDNA 9

Microarray probesets 3

less

MGI:2141189

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Get4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49494	Chr5:139238069-139238084 (+)	-2 bp
Tssr49495	Chr5:139238098-139238210 (+)	75 bp
Tssr49496	Chr5:139238477-139238542 (+)	431 bp
Tssr49497	Chr5:139239244-139239274 (+)	1,180 bp
Tssr49498	Chr5:139242387-139242391 (+)	4,310 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24