Armc12 MGI Mouse Gene Detail - MGI:1914895 - armadillo repeat containing 12

Symbol

Armc12
Name

armadillo repeat containing 12
Synonyms

4930511I11Rik

Feature Type

protein coding gene
IDs

MGI:1914895
NCBI Gene: 67645
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr17:28749835-28757949 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 14.74 cM
Mapping Data

2 experiments

SNPs within 2kb

200 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914895	protein coding gene	Chr17:28749780-28758084 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023442	protein coding gene	Chr17:27946609-27957841 (+)
A/J	MGP_AJ_G0023400	protein coding gene	Chr17:27014471-27022673 (+)
AKR/J	MGP_AKRJ_G0023365	protein coding gene	Chr17:27222761-27232353 (+)
BALB/cJ	MGP_BALBcJ_G0023405	protein coding gene	Chr17:27285899-27298215 (+)
C3H/HeJ	MGP_C3HHeJ_G0023166	protein coding gene	Chr17:27609819-27618412 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023847	protein coding gene	Chr17:29075202-29088109 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021322	protein coding gene	Chr17:24383461-24392193 (+)
CAST/EiJ	MGP_CASTEiJ_G0022667	protein coding gene	Chr17:27590293-27598613 (+)
CBA/J	MGP_CBAJ_G0023140	protein coding gene	Chr17:30116238-30132843 (+)
DBA/2J	MGP_DBA2J_G0023271	protein coding gene	Chr17:26572872-26580873 (+)
FVB/NJ	MGP_FVBNJ_G0023241	protein coding gene	Chr17:26386782-26409482 (+)
LP/J	MGP_LPJ_G0023349	protein coding gene	Chr17:28204205-28213779 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023259	protein coding gene	Chr17:29534557-29544306 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023889	protein coding gene	Chr17:27662678-27670771 (+)
PWK/PhJ	MGP_PWKPhJ_G0022417	protein coding gene	Chr17:25391548-25400011 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022235	protein coding gene	Chr17:25641525-25649133 (+)
WSB/EiJ	MGP_WSBEiJ_G0022729	protein coding gene	Chr17:27651428-27660978 (+)

Human Ortholog

ARMC12, armadillo repeat containing 12

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARMC12, armadillo repeat containing 12
Synonyms

C6orf81, SPGF90
Links

HGNC:21099

NCBI Gene ID: 221481

neXtProt AC: NX_Q5T9G4

UniProt: Q5T9G4
Chr Location

6p21.31; chr6:35731524-35749079 (+) GRCh38

MGI Vertebrate Homology

Armc12 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ARMC12
Gene Tree

Armc12

Diseases

1 with human ARMC12 associations

				Human Disease	Mouse Models
				spermatogenic failure 90 IDs spermatogenic failure 90 DOID:0070589 OMIM:620744

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 3 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

5
Gene trapped

1
Targeted

2
Transgenic

1
Incidental Mutations

APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit male infertility associated with abnormal sperm flagellum morphology and function.

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All GO Annotations

16
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

2
UniProt

5
CCDS

CCDS28579.1

Ensembl

ENSMUSG00000024223 (Evidence)
NCBI Gene

67645

			Length	Strain/Species	Flank
genomic	67645	NCBI Gene Model \| MGI Sequence Detail	8115	C57BL/6J	± kb
transcript	NM_026290	RefSeq \| MGI Sequence Detail	1103	C57BL/6
polypeptide	Q80X86	UniProt \| EBI \| MGI Sequence Detail	340	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000031954 armadillo repeat-containing protein 12

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR006911 Armadillo repeat-containing domain

IPR042834 Armadillo repeat-containing protein 12

IPR016024 Armadillo-type fold

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All nucleic 8

cDNA 8

Microarray probesets 2

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MGI:2147014

Summaries

All 26

Gene Ontology 5

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:352415 Liu W, et al., Biallelic mutations in ARMC12 cause asthenozoospermia and multiple midpiece defects in humans and mice. J Med Genet. 2023 Feb;60(2):154-162

TSS for Armc12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143437	Chr17:28749802-28749807 (+)	-30 bp
Tssr143438	Chr17:28749808-28749853 (+)	-4 bp
Tssr143439	Chr17:28751145-28751175 (+)	1,325 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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