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Sdhb Gene Detail
Summary
  • Symbol
    Sdhb
  • Name
    succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
  • Synonyms
    0710008N11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914930
    NCBI Gene: 67680
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:140688582-140706509 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 73.24 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    627 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914930
 protein coding gene Chr4:140688514-140706509 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029033
 protein coding gene Chr4:143949913-143968983 (+)
A/J MGP_AJ_G0028992
 protein coding gene Chr4:137720212-137739253 (+)
AKR/J MGP_AKRJ_G0028944
 protein coding gene Chr4:141690463-141708423 (+)
BALB/cJ MGP_BALBcJ_G0029016
 protein coding gene Chr4:138407807-138426076 (+)
C3H/HeJ MGP_C3HHeJ_G0028730
 protein coding gene Chr4:142074960-142093680 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029457
 protein coding gene Chr4:149004666-149027146 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026728
 protein coding gene Chr4:130636318-130654132 (+)
CAST/EiJ MGP_CASTEiJ_G0028162
 protein coding gene Chr4:140322641-140344806 (+)
CBA/J MGP_CBAJ_G0028694
 protein coding gene Chr4:153290039-153308175 (+)
DBA/2J MGP_DBA2J_G0028844
 protein coding gene Chr4:138114144-138132561 (+)
FVB/NJ MGP_FVBNJ_G0028811
 protein coding gene Chr4:137213366-137231838 (+)
LP/J MGP_LPJ_G0028943
 protein coding gene Chr4:143982374-144000815 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028837
 protein coding gene Chr4:157153759-157176901 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029495
 protein coding gene Chr4:142213791-142231551 (+)
PWK/PhJ MGP_PWKPhJ_G0027883
 protein coding gene Chr4:134988043-135014597 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027708
 protein coding gene Chr4:138043832-138061704 (+)
WSB/EiJ MGP_WSBEiJ_G0028240
 protein coding gene Chr4:142497672-142516821 (+)



Homology
more
  • Human Ortholog
    SDHB, succinate dehydrogenase complex iron sulfur subunit B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SDHB, succinate dehydrogenase complex iron sulfur subunit B
  • Synonyms
    CWS2, IP, MC2DN4, PGL4, PPGL4, SDH, SDH1, SDH2, SDHIP
  • Links
    NCBI Gene ID: 6390
    neXtProt AC: NX_P21912
    UniProt: P21912

  • Chr Location
    1p36.13; chr1:17018664-17054151 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sdhb mouse models; 5 with human SDHB associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The gene is involved in the hypoxia-induced RNA editing pathway in monocytes. Heterozygous compound KOs show reduced increase in blood hemoglobin under hypoxic conditions. Homozygous inactivation of this gene results in complete embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1057
  • Tissues
    131
  • cDNA Data
    259
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67680 NCBI Gene Model | MGI Sequence Detail 17928 C57BL/6J ±  kb
    transcript NM_023374 RefSeq | MGI Sequence Detail 1096 C57BL/6  
    polypeptide Q9CQA3 UniProt | EBI | MGI Sequence Detail 282 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000014564 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
      (term hierarchy)
    • EC
      1.1.5.-, 1.3.5.1
    • InterPro Domains
      IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
      IPR036010 2Fe-2S ferredoxin-like superfamily
      IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
      IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
      IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
      IPR009051 Alpha-helical ferredoxin
      IPR012675 Beta-grasp domain superfamily
      IPR025192 Succinate dehydogenase/fumarate reductase N-terminal
      IPR050573 Succinate Dehydrogenase/Fumarate Reductase Iron-Sulfur
      IPR004489 Succinate dehydrogenase/fumarate reductase iron-sulphur protein
    • GlyGen
      Q9CQA3 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 263
      cDNA 259
      Primer pair 4

      Microarray probesets 4
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 33
      Diseases 2
      Gene Ontology 19
      Phenotypes 25
    • Earliest
      J:320283 Corbin JD, et al., Studies of cGMP analog specificity and function of the two intrasubunit binding sites of cGMP-dependent protein kinase. J Biol Chem. 1986 Jan 25;261(3):1208-14
    • Latest
      J:357725 O'Carroll SM, et al., Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase. Nat Metab. 2024 Oct 15;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory