Wfdc2 MGI Mouse Gene Detail - MGI:1914951 - WAP four-disulfide core domain 2

Symbol

Wfdc2
Name

WAP four-disulfide core domain 2
Synonyms

1600023A02Rik, HE4, WAP5

Feature Type

protein coding gene
IDs

MGI:1914951
NCBI Gene: 67701
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:164404635-164410430 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 85.20 cM, cytoband H3
Mapping Data

4 experiments

SNPs within 2kb

305 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914951	protein coding gene	Chr2:164404333-164410430 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026857	protein coding gene	Chr2:170017741-170023835 (+)
A/J	MGP_AJ_G0026823	protein coding gene	Chr2:163094462-163100556 (+)
AKR/J	MGP_AKRJ_G0026794	protein coding gene	Chr2:167934995-167941089 (+)
BALB/cJ	MGP_BALBcJ_G0026832	protein coding gene	Chr2:163455157-163461251 (+)
C3H/HeJ	MGP_C3HHeJ_G0026574	protein coding gene	Chr2:168291465-168297562 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027280	protein coding gene	Chr2:174958653-174964750 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024650	protein coding gene	Chr2:156499188-156505325 (+)
CAST/EiJ	MGP_CASTEiJ_G0026034	protein coding gene	Chr2:168719631-168725964 (+)
CBA/J	MGP_CBAJ_G0026551	protein coding gene	Chr2:181292562-181298656 (+)
DBA/2J	MGP_DBA2J_G0026689	protein coding gene	Chr2:162264121-162270237 (+)
FVB/NJ	MGP_FVBNJ_G0026655	protein coding gene	Chr2:160682867-160689609 (+)
LP/J	MGP_LPJ_G0026792	protein coding gene	Chr2:170102352-170108446 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026675	protein coding gene	Chr2:184874005-184880099 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027336	protein coding gene	Chr2:167837759-167845190 (+)
PWK/PhJ	MGP_PWKPhJ_G0025771	protein coding gene	Chr2:161859232-161865536 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025572	protein coding gene	Chr2:166727538-166734382 (+)
WSB/EiJ	MGP_WSBEiJ_G0026105	protein coding gene	Chr2:168709122-168715282 (+)

Human Ortholog

WFDC2, WAP four-disulfide core domain 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WFDC2, WAP four-disulfide core domain 2
Synonyms

BENP, dJ461P17.6, EDDM4, HE4, WAP5
Links

HGNC:15939

NCBI Gene ID: 10406

neXtProt AC: NX_Q14508

UniProt: Q14508
Chr Location

20q13.12; chr20:45469753-45481532 (+) GRCh38

MGI Vertebrate Homology

Wfdc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WFDC2
Gene Tree

Wfdc2

less

Phenotype Summary

26 phenotypes from 4 alleles in 4 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

7
Gene trapped

2
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout affects lung development, leading to respiratory stress, cyanosis and death within hours after birth.

less

All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

834
Tissues

114
cDNA Data

71
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wfdc2

ZFIN wfdc2

less

All Sequences

47
RefSeq

4
UniProt

5
CCDS

CCDS17040.1, CCDS89579.1

Ensembl

ENSMUSG00000017723 (Evidence)
NCBI Gene

67701

			Length	Strain/Species	Flank
genomic	67701	NCBI Gene Model \| MGI Sequence Detail	5796	C57BL/6J	± kb
transcript	NM_026323	RefSeq \| MGI Sequence Detail	708	C57BL/6
polypeptide	Q9DAU7	UniProt \| EBI \| MGI Sequence Detail	174	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000031800 WAP four-disulfide core domain protein 2

(term hierarchy)
InterPro Domains

IPR036645 Elafin-like superfamily

IPR050514 WAP four-disulfide core domain

IPR008197 WAP-type 'four-disulfide core' domain

less

All nucleic 72

cDNA 71

Primer pair 1

Microarray probesets 4

Summaries

All 49

Developmental Gene Expression 11

Gene Ontology 3

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Wfdc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21613	Chr2:164404627-164404641 (+)	-1 bp
Tssr21614	Chr2:164405236-164405260 (+)	613 bp
Tssr21615	Chr2:164405334-164405350 (+)	707 bp
Tssr21616	Chr2:164406024-164406035 (+)	1,395 bp
Tssr21617	Chr2:164406073-164406093 (+)	1,448 bp
Tssr21618	Chr2:164410272-164410325 (+)	5,664 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24