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Slc25a37 Gene Detail
Summary
  • Symbol
    Slc25a37
  • Name
    solute carrier family 25, member 37
  • Synonyms
    1700020E22Rik, 4930513O14Rik, 4930526G11Rik, C330015G08Rik, Frascati, Mfrn, Mfrn1, mitoferrin, Mscp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914962
    NCBI Gene: 67712
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:69479297-69522561 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.03 cM, cytoband D1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    523 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914962
 protein coding gene Chr14:69479297-69522993 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021516
 protein coding gene Chr14:64010321-64058869 (-)
A/J MGP_AJ_G0021475
 protein coding gene Chr14:62496799-62542093 (-)
AKR/J MGP_AKRJ_G0021451
 protein coding gene Chr14:64593027-64636182 (-)
BALB/cJ MGP_BALBcJ_G0021481
 protein coding gene Chr14:62474222-62517749 (-)
C3H/HeJ MGP_C3HHeJ_G0021258
 protein coding gene Chr14:64319099-64363686 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021920
 protein coding gene Chr14:66933063-66978984 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019460
 protein coding gene Chr14:60336532-60380041 (-)
CAST/EiJ MGP_CASTEiJ_G0020775
 protein coding gene Chr14:60855504-60902035 (-)
CBA/J MGP_CBAJ_G0021225
 protein coding gene Chr14:69021012-69064302 (-)
DBA/2J MGP_DBA2J_G0021348
 protein coding gene Chr14:62097326-62141612 (-)
FVB/NJ MGP_FVBNJ_G0021327
 protein coding gene Chr14:61515261-61558989 (-)
LP/J MGP_LPJ_G0021423
 protein coding gene Chr14:65087791-65095546 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021356
 protein coding gene Chr14:67973531-68020011 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021943
 protein coding gene Chr14:63854538-63900208 (-)
PWK/PhJ MGP_PWKPhJ_G0020519
 protein coding gene Chr14:58845869-58890990 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020352
 protein coding gene Chr14:59781804-59824441 (-)
WSB/EiJ MGP_WSBEiJ_G0020828
 protein coding gene Chr14:64149861-64197365 (-)



Homology
more
  • Human Ortholog
    SLC25A37, solute carrier family 25 member 37
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A37, solute carrier family 25 member 37
  • Synonyms
    HT015, MFRN, MFRN1, MSC, MSCP, PRO1278, PRO1584, PRO2217
  • Links
    NCBI Gene ID: 51312
    neXtProt AC: NX_Q9NYZ2
    UniProt: Q9NYZ2

  • Chr Location
    8p21.2; chr8:23528956-23575463 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele are pale, exhibit no hemoglobinization in the yolk sac and heart, and die during organogenesis. Homozygous hepatocyte specific KO affects iron metabolism and oxidative phosphorylation in liver mitochondria leads to a reduction of liver regeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    26
  • cDNA Data
    13
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034248 Ensembl Gene Model | MGI Sequence Detail 43265 C57BL/6J ±  kb
    transcript ENSMUST00000037064 Ensembl | MGI Sequence Detail 4174 Not Applicable  
    polypeptide ENSMUSP00000039990 Ensembl | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 23
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1922377, MGI:1925436, MGI:1925952, MGI:2145697
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:321213 Zhang T, et al., ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1. Nat Cancer. 2022 Jan;3(1):75-89
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory