Gpatch2 MGI Mouse Gene Detail - MGI:1915019 - G patch domain containing 2

Symbol

Gpatch2
Name

G patch domain containing 2
Synonyms

5830433G22Rik, 5830436K05Rik, Gpatc2

Feature Type

protein coding gene
IDs

MGI:1915019
NCBI Gene: 67769
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:186947705-187083901 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 90.59 cM, cytoband H5
Mapping Data

3 experiments

SNPs within 2kb

3468 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915019	protein coding gene	Chr1:186946855-187103839 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016923	protein coding gene	Chr1:194018754-194164689 (+)
A/J	MGP_AJ_G0016902	protein coding gene	Chr1:186082574-186221070 (+)
AKR/J	MGP_AKRJ_G0016867	protein coding gene	Chr1:191558480-191699506 (+)
BALB/cJ	MGP_BALBcJ_G0016860	protein coding gene	Chr1:186755888-186891733 (+)
C3H/HeJ	MGP_C3HHeJ_G0016684	protein coding gene	Chr1:192426998-192572186 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017323	protein coding gene	Chr1:200218425-200365102 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015030	protein coding gene	Chr1:177059250-177205715 (+)
CAST/EiJ	MGP_CASTEiJ_G0016267	protein coding gene	Chr1:191935453-192079053 (+)
CBA/J	MGP_CBAJ_G0016658	protein coding gene	Chr1:207674470-207831208 (+)
DBA/2J	MGP_DBA2J_G0016764	protein coding gene	Chr1:184846567-184982169 (+)
FVB/NJ	MGP_FVBNJ_G0016760	protein coding gene	Chr1:182922780-183060291 (+)
LP/J	MGP_LPJ_G0016839	protein coding gene	Chr1:195192203-195337222 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016792	protein coding gene	Chr1:214492570-214642206 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017360	protein coding gene	Chr1:191465188-191604167 (+)
PWK/PhJ	MGP_PWKPhJ_G0016054	protein coding gene	Chr1:184063120-184199776 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015830	protein coding gene	Chr1:190423777-190559764 (+)
WSB/EiJ	MGP_WSBEiJ_G0016329	protein coding gene	Chr1:191645692-191788595 (+)

Human Ortholog

GPATCH2, G-patch domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPATCH2, G-patch domain containing 2
Synonyms

CT110, GPATC2, Pfa1, PPP1R30
Links

HGNC:25499

NCBI Gene ID: 55105

neXtProt AC: NX_Q9NW75

UniProt: Q9NW75
Chr Location

1q41; chr1:217426992-217631090 (-) GRCh38

MGI Vertebrate Homology

Gpatch2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPATCH2
Gene Tree

Gpatch2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

6
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available

Mice homozygous for a null allele display a small reduction in the frequency of B cells in the blood but no changes in TNF-mediated immune responses.

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

22
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpatch2

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All Sequences

98
RefSeq

25
UniProt

8
CCDS

CCDS15605.1, CCDS87940.1, CCDS87941.1, CCDS87942.1

Ensembl

ENSMUSG00000039210 (Evidence)
NCBI Gene

67769

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039210	Ensembl Gene Model \| MGI Sequence Detail	136197	C57BL/6J	± kb
transcript	ENSMUST00000065573	Ensembl \| MGI Sequence Detail	4547	Not Applicable
polypeptide	ENSMUSP00000065009	Ensembl \| MGI Sequence Detail	527	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000029518 G patch domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR000467 G-patch domain

IPR051189 Splicing-associated domain-containing protein

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All nucleic 23

cDNA 23

Microarray probesets 10

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MGI:1923285, MGI:2138233, MGI:2138241, MGI:2138559, MGI:2138591

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 4
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:336774 Dalseno D, et al., Deletion of Gpatch2 does not alter Tnf expression in mice. Cell Death Dis. 2023 Mar 27;14(3):214

TSS for Gpatch2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10643	Chr1:186947698-186947744 (+)	16 bp
Tssr10644	Chr1:186947745-186947756 (+)	46 bp
Tssr10645	Chr1:186947911-186947925 (+)	213 bp
Tssr10646	Chr1:186947934-186947945 (+)	235 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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