Arpc5 MGI Mouse Gene Detail - MGI:1915021 - actin related protein 2/3 complex, subunit 5

Symbol

Arpc5
Name

actin related protein 2/3 complex, subunit 5
Synonyms

5830443F10Rik, p16-Arc

Feature Type

protein coding gene
IDs

MGI:1915021
NCBI Gene: 67771
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:152642293-152651331 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 65.02 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

316 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915021	protein coding gene	Chr1:152642293-152651348 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016590	protein coding gene	Chr1:157536274-157546830 (+)
A/J	MGP_AJ_G0016572	protein coding gene	Chr1:151193009-151202062 (+)
AKR/J	MGP_AKRJ_G0016537	protein coding gene	Chr1:155854552-155864820 (+)
BALB/cJ	MGP_BALBcJ_G0016532	protein coding gene	Chr1:151765814-151775035 (+)
C3H/HeJ	MGP_C3HHeJ_G0016357	protein coding gene	Chr1:155971648-155980734 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016993	protein coding gene	Chr1:162989879-162999752 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014702	protein coding gene	Chr1:143511484-143521105 (+)
CAST/EiJ	MGP_CASTEiJ_G0015936	protein coding gene	Chr1:155474838-155484032 (+)
CBA/J	MGP_CBAJ_G0016331	protein coding gene	Chr1:168720937-168732952 (+)
DBA/2J	MGP_DBA2J_G0016437	protein coding gene	Chr1:150208206-150217279 (+)
FVB/NJ	MGP_FVBNJ_G0016435	protein coding gene	Chr1:148694759-148703830 (+)
LP/J	MGP_LPJ_G0016508	protein coding gene	Chr1:158649233-158660559 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016461	protein coding gene	Chr1:176370687-176380873 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017029	protein coding gene	Chr1:155641600-155651084 (+)
PWK/PhJ	MGP_PWKPhJ_G0015722	protein coding gene	Chr1:149217208-149231325 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015509	protein coding gene	Chr1:154449125-154458113 (+)
WSB/EiJ	MGP_WSBEiJ_G0015999	protein coding gene	Chr1:155705686-155715366 (+)

Human Ortholog

ARPC5, actin related protein 2/3 complex subunit 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARPC5, actin related protein 2/3 complex subunit 5
Synonyms

ARC16, dJ127C7.3, IMD113, p16-Arc
Links

HGNC:708

NCBI Gene ID: 10092

neXtProt AC: NX_O15511

UniProt: O15511
Chr Location

1q25.3; chr1:183620846-183635783 (-) GRCh38

MGI Vertebrate Homology

Arpc5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARPC5
Protein SuperFamily

p16-ARC
Gene Tree

Arpc5

Diseases

1 with human ARPC5 associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

2 involving Arpc5
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality between E9.5 and E10.5 with incomplete caudal and rostral neuropore closure, absent pharyngeal arches and cardiac outflow tract, impaired somite development, and failure of initiation of embryo turning.

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All GO Annotations

30
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

395
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arpc5

ZFIN arpc5a

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All Sequences

78
RefSeq

2
UniProt

5
CCDS

CCDS35739.1

Ensembl

ENSMUSG00000008475 (Evidence)
NCBI Gene

67771

			Length	Strain/Species	Flank
genomic	67771	NCBI Gene Model \| MGI Sequence Detail	9039	C57BL/6J	± kb
transcript	NM_026369	RefSeq \| MGI Sequence Detail	1897	C57BL/6
polypeptide	Q9CPW4	UniProt \| EBI \| MGI Sequence Detail	151	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004313 actin-related protein 2/3 complex subunit 5

(term hierarchy)
PDB

7AQK
InterPro Domains

IPR006789 Actin-related protein 2/3 complex subunit 5

IPR036743 Actin-related protein 2/3 complex subunit 5 superfamily

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All nucleic 395

cDNA 395

Microarray probesets 3

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:334465 Sindram E, et al., ARPC5 deficiency leads to severe early-onset systemic inflammation and mortality. Dis Model Mech. 2023 Jul 1;16(7)

TSS for Arpc5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9418	Chr1:152642291-152642302 (+)	4 bp
Tssr9419	Chr1:152642342-152642438 (+)	97 bp
Tssr9420	Chr1:152642444-152642461 (+)	160 bp
Tssr9421	Chr1:152643740-152643745 (+)	1,450 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24