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Kat8 Gene Detail
Summary
  • Symbol
    Kat8
  • Name
    K(lysine) acetyltransferase 8
  • Synonyms
    2010203C02Rik, 5830450F21Rik, D7Ertd629e, MOF, Myst1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915023
    NCBI Gene: 67773
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127511689-127525010 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    366 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915023
 protein coding gene Chr7:127511688-127525010 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033064
 protein coding gene Chr7:132302006-132315370 (+)
A/J MGP_AJ_G0033047
 protein coding gene Chr7:128757868-128771356 (+)
AKR/J MGP_AKRJ_G0032979
 protein coding gene Chr7:132086346-132105312 (+)
BALB/cJ MGP_BALBcJ_G0033048
 protein coding gene Chr7:128409594-128427525 (+)
C3H/HeJ MGP_C3HHeJ_G0032762
 protein coding gene Chr7:131991242-132007057 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033557
 protein coding gene Chr7:137450431-137463749 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030530
 protein coding gene Chr7:129946623-129959111 (+)
CAST/EiJ MGP_CASTEiJ_G0032091
 protein coding gene Chr7:123785858-123800353 (+)
CBA/J MGP_CBAJ_G0032735
 protein coding gene Chr7:142119722-142134174 (+)
DBA/2J MGP_DBA2J_G0032887
 protein coding gene Chr7:126733827-126747136 (+)
FVB/NJ MGP_FVBNJ_G0032840
 protein coding gene Chr7:126596007-126609305 (+)
LP/J MGP_LPJ_G0032981
 protein coding gene Chr7:133769149-133782416 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032872
 protein coding gene Chr7:143185090-143199453 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033577
 protein coding gene Chr7:131075815-131089544 (+)
PWK/PhJ MGP_PWKPhJ_G0031798
 protein coding gene Chr7:119741809-119755495 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031644
 protein coding gene Chr7:117887485-117900365 (+)
WSB/EiJ MGP_WSBEiJ_G0032203
 protein coding gene Chr7:132041531-132054836 (+)



Homology
more
  • Human Ortholog
    KAT8, lysine acetyltransferase 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KAT8, lysine acetyltransferase 8
  • Synonyms
    hMOF, LIGOWS, MOF, MYST1, ZC2HC8
  • Links
    NCBI Gene ID: 84148
    neXtProt AC: NX_Q9H7Z6
    UniProt: Q9H7Z6

  • Chr Location
    16p11.2; chr16:31114489-31131393 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 5 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die prior to gastrulation. Mice homozygous for a floxed allele deleted in the brain exhibit prenatal lethality, intraventricular hemorrhage, enlarged lateral ventricles, and abnormal brain vasculature.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    95
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    897
  • Tissues
    140
  • cDNA Data
    13
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67773 NCBI Gene Model | MGI Sequence Detail 13322 C57BL/6J ±  kb
    transcript NM_026370 RefSeq | MGI Sequence Detail 1579 C57BL/6  
    polypeptide Q9D1P2 UniProt | EBI | MGI Sequence Detail 458 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 14
      Primer pair 4
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1289157, MGI:1923942
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 12
      Gene Ontology 23
      Phenotypes 37
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:359001 Hu Y, et al., Mitochondrial MOF regulates energy metabolism in heart failure via ATP5B hyperacetylation. Cell Rep. 2024 Oct 22;43(10):114839
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory