Rtp4 MGI Mouse Gene Detail - MGI:1915025 - receptor transporter protein 4

Symbol

Rtp4
Name

receptor transporter protein 4
Synonyms

5830458K16Rik

Feature Type

protein coding gene
IDs

MGI:1915025
NCBI Gene: 67775
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr16:23339041-23432972 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 14.55 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

2497 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915025	protein coding gene	Chr16:23338976-23432972 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022685	protein coding gene	Chr16:21198072-21202254 (+)
A/J	MGP_AJ_G0022647	protein coding gene	Chr16:20190562-20194891 (+)
AKR/J	MGP_AKRJ_G0022621	protein coding gene	Chr16:21052195-21056446 (+)
BALB/cJ	MGP_BALBcJ_G0022652	protein coding gene	Chr16:20388987-20393527 (+)
C3H/HeJ	MGP_C3HHeJ_G0022416	protein coding gene	Chr16:21162110-21166360 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023101	protein coding gene	Chr16:21734852-21739087 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020619	protein coding gene	Chr16:20827210-20829769 (+)
CAST/EiJ	MGP_CASTEiJ_G0021945	protein coding gene	Chr16:21154058-21160888 (+)
CBA/J	MGP_CBAJ_G0022387	protein coding gene	Chr16:22602135-22609470 (+)
DBA/2J	MGP_DBA2J_G0022519	protein coding gene	Chr16:20144552-20150883 (+)
FVB/NJ	MGP_FVBNJ_G0022495	protein coding gene	Chr16:20148546-20152775 (+)
LP/J	MGP_LPJ_G0022587	protein coding gene	Chr16:20989512-20993697 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022514	protein coding gene	Chr16:22105226-22110757 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023113	protein coding gene	Chr16:21004319-21008513 (+)
PWK/PhJ	MGP_PWKPhJ_G0021684	protein coding gene	Chr16:20424763-20429094 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021515	protein coding gene	Chr16:20732042-20737324 (+)
WSB/EiJ	MGP_WSBEiJ_G0021989	protein coding gene	Chr16:20956264-20960434 (+)

Human Ortholog

RTP4, receptor transporter protein 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RTP4, receptor transporter protein 4
Synonyms

IFRG28, Z3CXXC4
Links

HGNC:23992

NCBI Gene ID: 64108

neXtProt AC: NX_Q96DX8

UniProt: Q96DX8
Chr Location

3q27.3; chr3:187368385-187372076 (+) GRCh38

MGI Vertebrate Homology

Rtp4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RTP4
Gene Tree

Rtp4

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout reduces susceptibility to parasitic and viral infection.

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

46
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

51
RefSeq

10
UniProt

5
CCDS

CCDS28079.1

Ensembl

ENSMUSG00000033355 (Evidence)
NCBI Gene

67775

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033355	Ensembl Gene Model \| MGI Sequence Detail	93932	C57BL/6J	± kb
transcript	ENSMUST00000209422	Ensembl \| MGI Sequence Detail	1859	Not Applicable
polypeptide	ENSMUSP00000147521	Ensembl \| MGI Sequence Detail	249	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014356 receptor-transporting protein 4

(term hierarchy)
InterPro Domains

IPR026096 Receptor-transporting protein

IPR027377 ZAR1/RTP1-5-like, 3CxxC-type zinc finger

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All nucleic 46

cDNA 46

Microarray probesets 3

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rtp4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137722	Chr16:23428645-23428711 (+)	89,637 bp
Tssr137723	Chr16:23428712-23428749 (+)	89,690 bp
Tssr137724	Chr16:23428750-23428782 (+)	89,725 bp
Tssr137725	Chr16:23428819-23428832 (+)	89,785 bp
Tssr137726	Chr16:23430130-23430157 (+)	91,103 bp
Tssr137727	Chr16:23431620-23431645 (+)	92,592 bp
Tssr137728	Chr16:23431699-23431728 (+)	92,673 bp
Tssr137729	Chr16:23431891-23431928 (+)	92,869 bp
Tssr137730	Chr16:23432037-23432069 (+)	93,012 bp
Tssr137731	Chr16:23432101-23432115 (+)	93,067 bp
Tssr137732	Chr16:23432119-23432163 (+)	93,100 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24