Ilf2 MGI Mouse Gene Detail - MGI:1915031 - interleukin enhancer binding factor 2

Symbol

Ilf2
Name

interleukin enhancer binding factor 2
Synonyms

6230405A16Rik, TEG-267, Tex261, Tex267

Feature Type

protein coding gene
IDs

MGI:1915031
NCBI Gene: 67781
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr3:90383433-90395686 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.23 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

360 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915031	protein coding gene	Chr3:90383421-90395686 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027465	protein coding gene	Chr3:90793555-90807670 (+)
A/J	MGP_AJ_G0027429	protein coding gene	Chr3:87767270-87779516 (+)
AKR/J	MGP_AKRJ_G0027394	protein coding gene	Chr3:89916275-89940150 (+)
BALB/cJ	MGP_BALBcJ_G0027438	protein coding gene	Chr3:87722311-87735550 (+)
C3H/HeJ	MGP_C3HHeJ_G0027180	protein coding gene	Chr3:90090405-90102660 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027884	protein coding gene	Chr3:94201004-94213853 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025237	protein coding gene	Chr3:83259613-83271953 (+)
CAST/EiJ	MGP_CASTEiJ_G0026626	protein coding gene	Chr3:90480834-90492913 (+)
CBA/J	MGP_CBAJ_G0027155	protein coding gene	Chr3:97419616-97431868 (+)
DBA/2J	MGP_DBA2J_G0027292	protein coding gene	Chr3:87133240-87145309 (+)
FVB/NJ	MGP_FVBNJ_G0027260	protein coding gene	Chr3:85456927-85480148 (+)
LP/J	MGP_LPJ_G0027401	protein coding gene	Chr3:91854588-91867870 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027281	protein coding gene	Chr3:103648181-103661520 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027943	protein coding gene	Chr3:89674915-89687684 (+)
PWK/PhJ	MGP_PWKPhJ_G0026360	protein coding gene	Chr3:87028665-87041143 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026180	protein coding gene	Chr3:88847889-88859847 (+)
WSB/EiJ	MGP_WSBEiJ_G0026708	protein coding gene	Chr3:90081349-90093440 (+)

Human Ortholog

ILF2, interleukin enhancer binding factor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ILF2, interleukin enhancer binding factor 2
Synonyms

NF45, PRO3063
Links

HGNC:6037

NCBI Gene ID: 3608

neXtProt AC: NX_Q12905

UniProt: Q12905
Chr Location

1q21.3; chr1:153661788-153671028 (-) GRCh38

MGI Vertebrate Homology

Ilf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ILF2
Gene Tree

Ilf2

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

22
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Ilf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality.

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All GO Annotations

23
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

848
Tissues

40
cDNA Data

17
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ilf2

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All Sequences

50
RefSeq

4
UniProt

2
CCDS

CCDS17530.1

Ensembl

ENSMUSG00000001016 (Evidence)
NCBI Gene

67781

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001016	Ensembl Gene Model \| MGI Sequence Detail	12254	C57BL/6J	± kb
transcript	ENSMUST00000001042	Ensembl \| MGI Sequence Detail	2027	Not Applicable
polypeptide	ENSMUSP00000001042	Ensembl \| MGI Sequence Detail	390	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009007 interleukin enhancer-binding factor 2

(term hierarchy)
PDB

4AT7, 4AT8, 4AT9, 4ATB
InterPro Domains

IPR006561 DZF domain

IPR049402 DZF domain, C-terminal

IPR049401 DZF domain, N-terminal

IPR052134 Interleukin enhancer-binding factor 2

IPR043519 Nucleotidyltransferase superfamily
GlyGen

Q9CXY6 1 site, 1 O-linked glycan (1 site)

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 5

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MGI:1096576

Summaries

All 48

Developmental Gene Expression 5

Diseases 1

Gene Ontology 5

Phenotypes 15
Earliest

J:35463 Lopez-Fernandez LA, et al., Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. Mamm Genome. 1996 Sep;7(9):698-700
Latest

J:344090 Lai S, et al., NF90-NF45 is essential for beta cell compensation under obesity-inducing metabolic stress through suppression of p53 signaling pathway. Sci Rep. 2022 May 25;12(1):8837

TSS for Ilf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30205	Chr3:90383428-90383527 (+)	45 bp
Tssr30206	Chr3:90391838-90391846 (+)	8,409 bp
Tssr944	Chr3:90395240-90395244 (+)	11,809 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24