Ahctf1 MGI Mouse Gene Detail - MGI:1915033 - AT hook containing transcription factor 1

Symbol

Ahctf1
Name

AT hook containing transcription factor 1
Synonyms

6230412P20Rik, Elys

Feature Type

protein coding gene
IDs

MGI:1915033
NCBI Gene: 226747
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr1:179572459-179631245 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 83.62 cM
Mapping Data

3 experiments

SNPs within 2kb

1168 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915033	protein coding gene	Chr1:179572459-179631580 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016863	protein coding gene	Chr1:186126642-186187299 (-)
A/J	MGP_AJ_G0016842	protein coding gene	Chr1:178618868-178677536 (-)
AKR/J	MGP_AKRJ_G0016808	protein coding gene	Chr1:183932625-183991441 (-)
BALB/cJ	MGP_BALBcJ_G0016800	protein coding gene	Chr1:179250447-179309083 (-)
C3H/HeJ	MGP_C3HHeJ_G0016625	protein coding gene	Chr1:184689632-184749320 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017263	protein coding gene	Chr1:192160252-192219478 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014971	protein coding gene	Chr1:169606904-169665816 (-)
CAST/EiJ	MGP_CASTEiJ_G0016206	protein coding gene	Chr1:183991756-184053046 (-)
CBA/J	MGP_CBAJ_G0016599	protein coding gene	Chr1:199314917-199373458 (-)
DBA/2J	MGP_DBA2J_G0016705	protein coding gene	Chr1:177461687-177520361 (-)
FVB/NJ	MGP_FVBNJ_G0016701	protein coding gene	Chr1:175545508-175606803 (-)
LP/J	MGP_LPJ_G0016779	protein coding gene	Chr1:187401814-187460773 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016732	protein coding gene	Chr1:206458333-206526119 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017300	protein coding gene	Chr1:183676769-183738198 (-)
PWK/PhJ	MGP_PWKPhJ_G0015994	protein coding gene	Chr1:176544044-176603273 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015770	protein coding gene	Chr1:182623843-182682078 (-)
WSB/EiJ	MGP_WSBEiJ_G0016269	protein coding gene	Chr1:183899478-183961090 (-)

Human Ortholog

AHCTF1, AT-hook containing transcription factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AHCTF1, AT-hook containing transcription factor 1
Synonyms

ELYS, MST108, MSTP108, TMBS62
Links

HGNC:24618

NCBI Gene ID: 25909

neXtProt AC: NX_Q8WYP5

UniProt: Q8WYP5
Chr Location

1q44; chr1:246839098-246931948 (-) GRCh38

MGI Vertebrate Homology

Ahctf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AHCTF1
Gene Tree

Ahctf1

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

30
Targeted

3
Genomic Mutations

2 involving Ahctf1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

113 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice die between E3.5 and E5.5. The inner cell mass cells exhibit impaired proliferation and apoptosis when grown in culture.

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All GO Annotations

30
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

933
Tissues

203
cDNA Data

297
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ahctf1

ZFIN ahctf1

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All Sequences

57
RefSeq

2
UniProt

6
CCDS

CCDS15564.1

Ensembl

ENSMUSG00000026491 (Evidence)
NCBI Gene

226747

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026491	Ensembl Gene Model \| MGI Sequence Detail	58787	C57BL/6J	± kb
transcript	ENSMUST00000027768	Ensembl \| MGI Sequence Detail	8506	Not Applicable
polypeptide	ENSMUSP00000027768	Ensembl \| MGI Sequence Detail	2243	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000003853 AT-hook-containing transcription factor 1

(term hierarchy)
PDB

4I0O
InterPro Domains

IPR032040 ELYS, beta-propeller domain

IPR025151 ELYS-like domain

IPR052620 ELYS/MEL-28 Nuclear Assembly Factor
GlyGen

Q8CJF7 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 301

cDNA 299

Primer pair 2

Microarray probesets 6

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MGI:2138514

Summaries

All 52

Developmental Gene Expression 9

Gene Ontology 8

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ahctf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15515	Chr1:179631419-179631457 (-)	-193 bp
Tssr15514	Chr1:179631393-179631411 (-)	-157 bp
Tssr15513	Chr1:179631268-179631279 (-)	-29 bp
Tssr15512	Chr1:179631190-179631267 (-)	16 bp
Tssr15511	Chr1:179631171-179631189 (-)	65 bp
Tssr15510	Chr1:179630781-179630787 (-)	461 bp
Tssr15509	Chr1:179630758-179630779 (-)	476 bp
Tssr15508	Chr1:179630729-179630735 (-)	513 bp
Tssr15507	Chr1:179630637-179630674 (-)	589 bp
Tssr15506	Chr1:179630064-179630086 (-)	1,170 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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