Sec14l2 MGI Mouse Gene Detail - MGI:1915065 - SEC14-like lipid binding 2

Symbol

Sec14l2
Name

SEC14-like lipid binding 2
Synonyms

1300013M05Rik, Spf, tap

Feature Type

protein coding gene
IDs

MGI:1915065
NCBI Gene: 67815
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:4047039-4068729 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 2.87 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

498 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915065	protein coding gene	Chr11:4047039-4073415 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017974	protein coding gene	Chr11:1020337-1051559 (-)
A/J	MGP_AJ_G0017947	protein coding gene	Chr11:1040301-1066742 (-)
AKR/J	MGP_AKRJ_G0017911	protein coding gene	Chr11:1089420-1118741 (-)
BALB/cJ	MGP_BALBcJ_G0017915	protein coding gene	Chr11:1008056-1035103 (-)
C3H/HeJ	MGP_C3HHeJ_G0017728	protein coding gene	Chr11:987703-1014181 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018368	protein coding gene	Chr11:1107777-1135365 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016026	protein coding gene	Chr11:918623-943896 (-)
CAST/EiJ	MGP_CASTEiJ_G0017290	protein coding gene	Chr11:951748-977769 (-)
CBA/J	MGP_CBAJ_G0017703	protein coding gene	Chr11:1331349-1368817 (-)
DBA/2J	MGP_DBA2J_G0017814	protein coding gene	Chr11:940730-967654 (-)
FVB/NJ	MGP_FVBNJ_G0017805	protein coding gene	Chr11:974041-1008173 (-)
LP/J	MGP_LPJ_G0017884	protein coding gene	Chr11:1133658-1160185 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017831	protein coding gene	Chr11:1017057-1043521 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018407	protein coding gene	Chr11:1089917-1121715 (-)
PWK/PhJ	MGP_PWKPhJ_G0017071	protein coding gene	Chr11:941040-967699 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016867	protein coding gene	Chr11:1041184-1066799 (-)
WSB/EiJ	MGP_WSBEiJ_G0017344	protein coding gene	Chr11:965232-991335 (-)

Human Ortholog

SEC14L2, SEC14 like lipid binding 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SEC14L2, SEC14 like lipid binding 2
Synonyms

C22orf6, SPF, TAP, TAP1
Links

HGNC:10699

NCBI Gene ID: 23541

neXtProt AC: NX_O76054

UniProt: O76054
Chr Location

22q12.2; chr22:30396941-30425303 (+) GRCh38

MGI Vertebrate Homology

Sec14l2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SEC14L2
Gene Tree

Sec14l2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased cholesterol synthesis and plasma levels under fasting conditions compared to wild-type mice.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

74
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

2
UniProt

1
CCDS

CCDS24377.1

Ensembl

ENSMUSG00000003585 (Evidence)
NCBI Gene

67815

			Length	Strain/Species	Flank
genomic	67815	NCBI Gene Model \| MGI Sequence Detail	21691	C57BL/6J	± kb
transcript	NM_144520	RefSeq \| MGI Sequence Detail	2529	C57BL/6
polypeptide	Q99J08	UniProt \| EBI \| MGI Sequence Detail	403	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014577 SEC14-like protein 2

(term hierarchy)
InterPro Domains

IPR001251 CRAL-TRIO lipid binding domain

IPR036865 CRAL-TRIO lipid binding domain superfamily

IPR011074 CRAL/TRIO, N-terminal domain

IPR036273 CRAL/TRIO, N-terminal domain superfamily

IPR009038 GOLD domain

IPR036598 GOLD domain superfamily

IPR051064 SEC14-like and CRAL-TRIO domain-containing protein
GlyGen

Q99J08 1 site, 1 O-linked glycan (1 site)

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All nucleic 76

Genomic 2

cDNA 74

Microarray probesets 2

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 7
Earliest

J:113817 Caras IW, et al., Interactions of supernatant protein factor with components of the microsomal squalene epoxidase system. Binding of supernatant protein factor to anionic phospholipids. J Biol Chem. 1980 Apr 25;255(8):3575-80
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Sec14l2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106538	Chr11:4068778-4068790 (-)	-55 bp
Tssr106537	Chr11:4068723-4068769 (-)	-17 bp
Tssr106536	Chr11:4068698-4068705 (-)	27 bp
Tssr106535	Chr11:4066711-4066744 (-)	2,001 bp
Tssr106534	Chr11:4054813-4054824 (-)	13,910 bp
Tssr106533	Chr11:4053797-4053801 (-)	14,930 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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