Atg3 MGI Mouse Gene Detail - MGI:1915091

Symbol

Atg3
Name

autophagy related 3
Synonyms

2610016C12Rik, APG3, Apg3l, PC3-96

Feature Type

protein coding gene
IDs

MGI:1915091
NCBI Gene: 67841
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr16:44979192-45008901 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 29.45 cM, cytoband B5
Mapping Data

2 experiments

SNPs within 2kb

726 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915091	protein coding gene	Chr16:44979148-45008901 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022849	protein coding gene	Chr16:43935079-43966212 (+)
A/J	MGP_AJ_G0022814	protein coding gene	Chr16:41956472-41989494 (+)
AKR/J	MGP_AKRJ_G0022786	protein coding gene	Chr16:43337161-43368675 (+)
BALB/cJ	MGP_BALBcJ_G0022815	protein coding gene	Chr16:41960319-41990023 (+)
C3H/HeJ	MGP_C3HHeJ_G0022579	protein coding gene	Chr16:43493364-43523084 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023262	protein coding gene	Chr16:44923774-44958102 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020776	protein coding gene	Chr16:42358378-42388144 (+)
CAST/EiJ	MGP_CASTEiJ_G0022104	protein coding gene	Chr16:43681312-43711923 (+)
CBA/J	MGP_CBAJ_G0022550	protein coding gene	Chr16:46831314-46861015 (+)
DBA/2J	MGP_DBA2J_G0022682	protein coding gene	Chr16:41703116-41733700 (+)
FVB/NJ	MGP_FVBNJ_G0022657	protein coding gene	Chr16:41622885-41652486 (+)
LP/J	MGP_LPJ_G0022750	protein coding gene	Chr16:43672426-43702149 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022676	protein coding gene	Chr16:46240750-46272430 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023277	protein coding gene	Chr16:43361916-43391621 (+)
PWK/PhJ	MGP_PWKPhJ_G0021844	protein coding gene	Chr16:42068080-42098194 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021675	protein coding gene	Chr16:43275638-43307327 (+)
WSB/EiJ	MGP_WSBEiJ_G0022149	protein coding gene	Chr16:43450307-43480816 (+)

Human Ortholog

ATG3, autophagy related 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATG3, autophagy related 3
Synonyms

APG3, APG3L, APG3-LIKE, hApg3, PC3-96
Links

HGNC:20962

NCBI Gene ID: 64422

neXtProt AC: NX_Q9NT62

UniProt: Q9NT62
Chr Location

3q13.2; chr3:112532510-112562046 (-) GRCh38

MGI Vertebrate Homology

Atg3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATG3
Gene Tree

Atg3

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Phenotype Summary

16 phenotypes from 3 alleles in 4 genetic backgrounds
2 phenotypes from multigenic genotypes
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

1
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in T cells exhibit decreased autophagy, decreased T cell proliferation, and increased T cell apoptosis. Mice homozygous for a knock-out allele exhibit decreased birth weight, neonatal lethality and abnormal autophagy.

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All GO Annotations

35
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

809
Tissues

67
cDNA Data

61
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atg3

ZFIN atg3

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All Sequences

42
RefSeq

4
UniProt

1
CCDS

CCDS28194.1

Ensembl

ENSMUSG00000022663 (Evidence)
NCBI Gene

67841

			Length	Strain/Species	Flank
genomic	67841	NCBI Gene Model \| MGI Sequence Detail	29710	C57BL/6J	± kb
transcript	NM_026402	RefSeq \| MGI Sequence Detail	2013	C57BL/6
polypeptide	Q9CPX6	UniProt \| EBI \| MGI Sequence Detail	314	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004413 ubiquitin-like-conjugating enzyme ATG3

(term hierarchy)
EC

2.3.2.-
InterPro Domains

IPR046962 Autophagy-related protein 3

IPR007135 Ubiquitin-like-conjugating enzyme Atg3/Atg10

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All nucleic 61

cDNA 61

Microarray probesets 4

Summaries

All 76

Developmental Gene Expression 3

Gene Ontology 15

Phenotypes 30
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:352038 Zhang Q, et al., Control of NAD(+) homeostasis by autophagic flux modulates mitochondrial and cardiac function. EMBO J. 2024 Feb;43(3):362-390

TSS for Atg3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138596	Chr16:44978741-44978753 (+)	-445 bp
Tssr138597	Chr16:44979088-44979173 (+)	-61 bp
Tssr138598	Chr16:44979183-44979202 (+)	1 bp
Tssr138599	Chr16:44979210-44979225 (+)	26 bp
Tssr138600	Chr16:44979232-44979284 (+)	66 bp
Tssr138601	Chr16:44979317-44979364 (+)	149 bp
Tssr138602	Chr16:44979369-44979380 (+)	183 bp
Tssr138603	Chr16:44979419-44979442 (+)	239 bp
Tssr138604	Chr16:44979450-44979473 (+)	270 bp
Tssr138605	Chr16:44982922-44982928 (+)	3,733 bp
Tssr138606	Chr16:44983605-44983651 (+)	4,436 bp
Tssr138607	Chr16:44990222-44990266 (+)	11,052 bp
Tssr138608	Chr16:44992082-44992099 (+)	12,899 bp
Tssr138609	Chr16:45005127-45005153 (+)	25,948 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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